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首页> 外文期刊>AIDS >Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease
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Markers of inflammation and activation of coagulation are associated with anaemia in antiretroviral-treated HIV disease

机译：炎症和凝血活化的标记与抗逆转录病毒治疗的艾滋病毒疾病中的贫血有关

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摘要

OBJECTIVE:: The objective of this study is to determine the relationship between inflammatory interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP)] and coagulation (D-dimer) biomarkers and the presence and type of anaemia among HIV-positive individuals. DESIGN:: A cross-sectional study. METHODS:: Combination antiretroviral therapy (cART)-treated adults participating in an international HIV trial with haemoglobin and mean corpuscular volume (MCV) measurements at entry were categorized by presence of anaemia (haemoglobin ≤14g/dl in men and ≤12g/dl in women) and, for those with anaemia, by type [microcytic (MCV<80fl), normocytic (80-100fl), macrocytic (>100fl)]. We analysed the association between inflammation (IL-6 and hsCRP) and coagulation (D-dimer) and haemoglobin, controlling for demographics (age, race and sex), BMI, HIV plasma RNA levels, CD4 T-cell counts (nadir and baseline), Karnofsky score, previous AIDS diagnosis, hepatitis B/C coinfection and use of zidovudine. RESULTS:: Among 1410 participants, 313 (22.2%) had anaemia. Of these, 4.1, 27.2 and 68.7% had microcytic, normocytic and macrocytic anaemia, respectively. When compared with participants with normal haemoglobin values, those with anaemia were more likely to be older, black, male and on zidovudine. They also had lower baseline CD4 T-cell counts and lower Karnofsky scores. Adjusted relative odds of anaemia per two-fold higher biomarker levels were 1.22 (P=0.007) for IL-6, 0.99 for hsCRP (P=0.86) and 1.35 (P<0.001) for D-dimer. Similar associations were seen in those with normal and high MCV values. CONCLUSION:: Persistent inflammation and hypercoagulation appear to be associated with anaemia. Routine measurements of haemoglobin might provide insights into the inflammatory state of treated HIV infection.
机译：目的：本研究的目的是确定炎症白细胞介素-6（IL-6）和高敏感性C反应蛋白（HSCRP）的关系和凝血（D-二聚体）生物标志物和贫血的存在和类型艾滋病毒阳性的个体。设计::横断面研究。方法::联合抗逆转录病毒治疗（购物车）治疗参与血红蛋白的国际艾滋病毒试验和进入的血小霉素（MCV）测量的成人被贫血存在（男性血红蛋白≤14G/ DL和≤12G/ DL中的血红蛋白≤14G/ DL）分类妇女），对于那些患有贫血的人，通过类型[微细胞（MCV <80FL），甘键（80-100FL），大核糖（> 100FL）]。我们分析了炎症（IL-6和HSCRP）和凝血（D-二聚体）和血红蛋白之间的关联，控制人口统计（年龄，种族和性别），BMI，HIV血浆RNA水平，CD4 T细胞计数（Nadir和基线） ），Karnofsky得分，以前的艾滋病诊断，乙型肝炎繁殖和使用Zidovudine。结果:: 1410名参与者中，313名（22.2％）有贫血。其中，4.1,27.2和68.7％分别具有微细胞，常规腺细胞和宏核贫血。与常规血红蛋白值的参与者相比，患有贫血的人更有可能是较大的，黑色，男性和齐凡押。它们还具有较低的基线CD4 T细胞计数和较低的Karnofsky评分。对于IL-6，对于IL-6，0.99的IL-6，对于D-二聚体的HSCRP（P <0.001），调整为每两倍较高的生物标志物水平的贫血的相对次数为1.22（p = 0.007）。在具有正常和高MCV值的那些中可以看到类似的关联。结论::持续炎症和高凝似乎与贫血有关。血红蛋白的常规测量可能会对治疗的HIV感染的炎症状态提供见解。

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  • 来源
    《AIDS》 |2014年第12期|共6页
  • 作者

    BorgesA.H.; WeitzJ.I.; CollinsG.; BakerJ.V.; LévyY.; DaveyR.T.; PhillipsA.N.; NeatonJ.D.; LundgrenJ.D.; DeeksS.G.;

  • 作者单位

    Centre for Health and Infectious Diseases Research (CHIP) Department of Infectious Diseases and;

    Thrombosis and Atherosclerosis Research Institute McMaster University Hamilton ON Canada;

    Department of Biostatistics United States;

    Department of Medicine University of Minnesota United States Hennepin County Medical Center;

    INSERM U955 Equipe 16 France Vaccine Research Institute (VRI) Université Paris Est Cré Teil;

    National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD;

    Research Department of Infection and Population Health University College London London United;

    Department of Biostatistics United States;

    Centre for Health and Infectious Diseases Research (CHIP) Department of Infectious Diseases and;

    Department of Medicine University of California San Francisco CA United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    anaemia; C-reactive protein; coagulation; D-dimer; HIV; inflammation; interleukin-6;

    机译：贫血;C反应蛋白;凝血;D-二聚体;艾滋病毒;炎症;白细胞介素-6;

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