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首页> 外文期刊>Crystal growth & design >Direct Growth of Microspheres on Amorphous Precursor Domains in Polymer-Controlled Crystallization of Indomethacin
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Direct Growth of Microspheres on Amorphous Precursor Domains in Polymer-Controlled Crystallization of Indomethacin

机译：吲哚美辛的聚合物控制结晶中非晶态前体域上微球的直接生长。

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摘要

Polymer-controlled crystallization is becoming an increasingly important approach to achieve functional materials precipitated from the solution phase. Nevertheless, there exist multiple pathways under the control of yet unpredictable kinetic factors, which significantly hinder the mechanistic understanding. Herein, the mechanistic study of polymer-controlled precipitation of a typical drug compound, indomethacin, was performed. The presence of a nonionic additive poly(vinylpyrrolidone) induces the heterogeneous nucleation of networks of dumbbell-shaped crystalline micro spheres on amorphous precursor domains, which is an emerging pathway in polymer-controlled crystallization. This pathway is also verified in the precipitation of L-histidine in the presence of poly(acrylic acid) in the current study. As a comparison, the presence of a cationic polymeric additive, branched polyethylenimine, promotes the formation of aggregates of amorphous nanoparticles and the subsequent crystallization of a spherical-shaped microsphere on each aggregate, a pathway in line with those in numerous studies of polymer-controlled crystallization of inorganic compounds. Our results suggest that the heterogeneous crystallization of microspheres on the amorphous precursor domains could be a specific pathway occurring in polymer-controlled precipitation of organic compounds mainly due to the fast kinetics of the precipitation process. In short, our study broadens our understanding of polymer-controlled crystallization of functional organic crystals.
机译：聚合物控制的结晶正成为一种越来越重要的方法，以实现从溶液相中沉淀出的功能材料。然而，在尚无法预测的动力学因素的控制下，存在多种途径，这极大地阻碍了对机理的理解。在此，进行了典型药物化合物吲哚美辛的聚合物控制沉淀的机理研究。非离子添加剂聚（乙烯基吡咯烷酮）的存在诱导非晶形前体域上的哑铃状晶体微球网络的异质成核，这是聚合物控制结晶的新兴途径。在当前研究中，在存在聚丙烯酸的情况下，L-组氨酸的沉淀也证实了该途径。相比之下，阳离子聚合添加剂支链聚乙烯亚胺的存在会促进无定形纳米粒子的聚集体的形成，并随后在每个聚集体上形成球形微球的结晶，这与许多聚合物控制研究一致无机化合物的结晶。我们的结果表明，微球在非晶态前体域上的异质结晶可能是有机物的聚合物控制沉淀过程中发生的特定途径，这主要归因于沉淀过程的快速动力学。简而言之，我们的研究拓宽了我们对功能性有机晶体的聚合物控制结晶的理解。

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