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首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus
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Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus

机译：NattOkinase，Probolytic酶，有效地缩小了鼻息肉组织并降低了粘液的粘度

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Abstract Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is often comorbid with asthma and resistant to therapeutic interventions. We recently reported that excessive fibrin deposition caused by impairment of fibrinolysis might play pivotal role in forming nasal polyp. Nattokinase (NK), a serine protease produced by Bacillus subtilis , has been reported to be a strong fibrinolytic enzyme. NK could be a promising drug candidate for use in the treatment of both CRSwNP and asthma. The objective of this study was to investigate the effects of NK on nasal polyp tissues from patients with CRSwNP. The nasal discharge from patients with CRSwNP and sputum from subjects with asthma were also used to investigate whether NK influences the viscosity of mucus. Methods To examine the effects on NK on nasal polyp tissues, pieces of nasal polyps were incubated either with saline or NK (10–1000?FU/ml) at 37?°C for 24?h. We assessed the presence of fibrin in nasal polyp tissue incubated with NK by means of immunohistochemistry. To examine the effects of NK on nasal discharge and sputum from patients with CRSwNP and asthma, respectively, were incubated with NK solution at 37?°C for 1?h. Results NK effectively shrinks the nasal polyp tissue through fibrin degradation. We also found that the viscosity of the nasal discharge and sputum from patients with CRSwNP and asthma, respectively, was significantly reduced by incubation with NK solution. Conclusions NK may be an effective alternative therapeutic option in patients with CRSwNP and comorbid asthma by causing fibrin degradation. ]]>
机译：摘要背景慢性鼻窦炎与鼻息息肉（CRSWNP）通常是具有哮喘和抗病性的哮喘和耐药干预措施。我们最近报道称，由于纤维蛋白溶解的损伤引起的过度纤维蛋白沉积可能在形成鼻息肉中发挥枢转作用。据报道，NattOkinase（NK）是由枯草芽孢杆菌产生的丝氨酸蛋白酶是强纤维蛋白溶解的酶。 NK可能是用于治疗CRSWNP和哮喘的有希望的药物候选者。本研究的目的是探讨NK对来自CRSWNP患者的鼻息肉组织的影响。来自CRSWNP患者和来自哮喘受试者的痰的鼻涕还用于研究NK是否会影响粘液的粘度。检查对NK对鼻息肉组织的影响的方法，将鼻息肉的碎片用盐水或NK（10-1000〜富/毫/ mL）温育27℃。通过免疫组化，我们评估了用NK孵育的鼻息肉组织中纤维蛋白的存在。为了分别检查NK对CRSWNP和哮喘患者的鼻排放和痰液的影响，将在37Ω℃下与NK溶液一起温育1℃。结果NK通过纤维蛋白降解有效地缩小了鼻息肉组织。我们还发现，通过与NK溶液孵育，分别从CRSWNP和哮喘患者中鼻涕和痰的粘度显着降低。结论NK可以通过引起纤维蛋白降解CRSWNP和合并哮喘患者有效的替代治疗选择。 ]]>

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