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Regulatory functions of B cells in allergic diseases

机译：B细胞在过敏性疾病中的调节功能

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摘要

B cells are essentially described for their capacity to produce antibodies ensuring anti-infectious immunity or deleterious responses in the case of autoimmunity or allergy. However, abundant data described their ability to restrain inflammation by diverse mechanisms. In allergy, some regulatory B-cell subsets producing IL-10 have been recently described as potent suppressive cells able to restrain inflammatory responses both in vitro and in vivo by regulatory T-cell differentiation or directly inhibiting T-cell-mediated inflammation. A specific deficit in regulatory B cells participates to more severe allergic inflammation. Induction of allergen tolerance through specific immunotherapy induces a specific expansion of these cells supporting their role in establishment of allergen tolerance. However, the regulatory functions carried out by B cells are not exclusively IL-10 dependent. Indeed, other regulatory mechanisms mediated by B cells are (i) the production of TGF-β, (ii) the promotion of T-cell apoptosis by Fas-Fas ligand or granzyme-B pathways, and (iii) their capacity to produce inhibitory IgG4 and sialylated IgG able to mediate anti-inflammatory mechanisms. This points to Bregs as interesting targets for the development of new therapies to induce allergen tolerance. In this review, we highlight advances in the study of regulatory mechanisms mediated by B cells and outline what is known about their phenotype as well as their suppressive role in allergy from studies in both mice and humans.
机译：B细胞基本上描述了它们在自身免疫或过敏的情况下产生抗传染性免疫或有害反应的抗体的能力。然而，丰富的数据描述了他们通过各种机制抑制炎症的能力。在过敏中，产生IL-10的一些调节B细胞亚群已被描述为能够通过调节T细胞分化或直接抑制T细胞介导的炎症来抑制体外和体内炎症反应的有效抑制细胞。调节B细胞的特定缺陷参与更严重的过敏性炎症。通过特定免疫疗法诱导过敏原耐受诱导这些细胞的特异性扩展，这些细胞支持其在建立过敏原耐受性方面的作用。然而，B细胞进行的调节功能不属于IL-10所属。实际上，B细胞介导的其他调节机制是（i）TGF-β的产生，（ii）Fas-Fas配体或Granzyme-B途径的T细胞凋亡，以及（iii）它们产生抑制的能力IgG4和唾液酸化IgG能够介导抗炎机制。这一点是贫困人士作为诱导过敏原耐受性的新疗法的有趣目标。在本综述中，我们突出了B细胞介导的调节机制研究的进展，并概述了其表型所知的内容以及对小鼠和人类的研究过敏的抑制作用。

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  • 来源
    《Allergy》 |2014年第11期|共10页
  • 作者

    BrazaF.; ChesneJ.; CastagnetS.; MagnanA.; BrouardS.;

  • 作者单位

    INSERM UMR 1087 L'Institut du ThoraxNantes France CNRS Institut de Transplantation Urologie N;

    INSERM UMR 1087 L'Institut du ThoraxNantes France CNRS Institut de Transplantation Urologie N;

    Laboratoire HLA établissement Fran?ais du SangNantes France;

    INSERM UMR 1087 L'Institut du ThoraxNantes France CNRS Institut de Transplantation Urologie N;

    INSERM Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire H?tel;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergy; B cells; IL-10; immunotherapy; regulatory B cells;

    机译：过敏;B细胞;IL-10;免疫疗法;监管B细胞;

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