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Biologically Triggered Delivery of EGF from Polymer Fiber Patches

机译：从聚合物纤维贴片生物触发EGF的递送

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src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-6/acsmacrolett.7b00212/20170614/images/medium/mz-2017-00212c_0006.gif">Wound healing is modulated by complex spatial and temporal regulation of growth factors within a wound site. Regenerative medicine seeks to generate materials that can mimic this environment for the healing of chronic or traumatic wounds. Herein, we report a programmed release of epidermal growth factor (EGF) from coextruded polymer fiber patches, which is triggered by the natural biological cascade of wound healing. Genetically engineered EGF containing a matrix metalloproteinase (MMP) cleavage site was covalently conjugated to a nonwoven poly(ε-caprolactone) (PCL) fiber mat fabricated by multilayered melt coextrusion. The genetically modified EGF showed rapid release in the presence of a biological trigger, MMP-9, while a control protein showed negligible release. The biologically responsive fiber mat dramatically enhanced proliferation and migration of human keratinocytes in the presence of MMP-9. This study describes the release of a critical wound-healing growth factor as triggered by the biology inherent in the healing process.
机译：src =“http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amlccd/2017/amlccd.2017.6.issue-6/acsmacrolett.7b002/20170614/image/medium/mz -2017-00212C_0006.gif“>伤口愈合是通过复杂的空间和伤口肿瘤内的生长因子调节来调节。再生药物寻求产生可以模仿这种环境的材料以慢性或创伤伤口的愈合。在此，我们报告了来自共挤出的聚合物纤维贴片的表皮生长因子（EGF）的编程释放，其被伤口愈合的天然生物级联引发。含有基质金属蛋白酶（MMP）切割位点的遗传工程EGF与由多层熔体共挤出制造的非织造聚（ε-己内酯）（PCL）纤维垫共价缀合。基因改性的EGF在存在生物触发，MMP-9的情况下显示出快速释放，而对照蛋白显示出可忽略不计的释放。生物响应性纤维垫在MMP-9存在下显着增强人角质形成细胞的增殖和迁移。本研究描述了临界伤口愈合生长因子的释放，其由愈合过程中固有的生物学引发。

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  • 来源
    《ACS Macro Letters》 |2017年第6期|共5页
  • 作者

    Si-Eun Kim; Parker W. Lee; Jonathan K. Pokorski;

  • 作者单位

    Department of Macromolecular Science and Engineering Case Western Reserve University Case School of Engineering Cleveland Ohio 44106 United States;

    Department of Macromolecular Science and Engineering Case Western Reserve University Case School of Engineering Cleveland Ohio 44106 United States;

    Department of Macromolecular Science and Engineering Case Western Reserve University Case School of Engineering Cleveland Ohio 44106 United States;

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  • 正文语种 eng
  • 中图分类 有机化学;
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