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首页> 外文期刊>Annals of allergy, asthma, and immunology >SUCCESSFUL DESENSITIZATION TO PACLITAXEL: A CASE REPORT
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SUCCESSFUL DESENSITIZATION TO PACLITAXEL: A CASE REPORT

机译：成功脱敏紫杉醇：案例报告

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IntroductionAntineoplastics are the third leading cause of death due to drug-induced anaphylaxis. Taxanes are an integral part of the chemotherapeutic regimen used in gynecological malignancies. Drug desensitization is a therapeutic technique that induces a temporary state of tolerance to a drug responsible for a hypersensitivity reaction. Case DescriptionA 48 year old female diagnosed with stage IV mixed epithelial ovarian cancer and arterial hypertension. Chemotherapy with carboplatin?+?paclitaxel is indicated, during the first cycle. She presents within the first 5 minutes of application of paclitaxel: lipotimia and wheals, without hypotension, hypoxemia, or wheezing. Skin tests are performed, resulting positive to paclitaxel at dilution 1:1000, a protocol of desensitization was performed based on 6 bags of sodium chloride, and paclitaxel in different concentrations. The desensitization doses were administered within six hours of preparation, and there was no reaction to the administration of the medication. DiscussionHypersensitivity reactions are common with the administration of taxanes. A desensitization protocol was performed, considering it successful since the patient was able to continue her treatment without adverse reactions.
机译：由于药物诱导的过敏症，引入诱导植物孢子体是第三次死亡原因。紫杉烷是在妇科恶性肿瘤中使用的化学治疗方案的一个组成部分。药物脱敏是一种治疗技术，其诱导对负责过敏反应的药物的暂时性耐受性。案例描述48岁女性被诊断为阶段IV混合上皮卵巢癌和动脉高血压。在第一个循环期间，指示含有卡铂的化疗？+？紫杉醇。她呈现在紫杉醇的前5分钟内：脂肪瘤和大风，没有低血压，低氧血症或喘息。进行皮肤测试，导致稀释的阳性为稀释，在稀释1：1000时，基于6只氯化钠和不同浓度的紫杉醇进行脱敏方案。在制备六小时内施用脱敏剂量，并且对药物的给药没有反应。浅谈与紫杉烷的给药是常见的。考虑到患者能够在没有不良反应的情况下继续治疗以来，考虑到脱敏方案。

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