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首页> 外文期刊>Annual review of cell and developmental biology >Kidney Nephron Determination
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Kidney Nephron Determination

机译：肾脏肾脏确定

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The nephron is a multifunctional filtration device equipped with an array of sophisticated sensors. For appropriate physiological function in the human and mouse, nephrons must be stereotypically arrayed in large numbers, and this essential structural property that defines the kidney is determined during its fetal development. This review explores the process of nephron determination in the fetal kidney, providing an overview of the foundational literature in the field as well as exploring new developments in this dynamic research area. Mechanisms that ensure that a large number of nephrons can be formed from a small initial number of progenitor cells are central to this process, and the question of how the nephron progenitor cell population balances epithelial differentiation with renewal in the progenitor state is a subject of particular interest. Key growth factor signaling pathways and transcription factor networks are discussed.
机译：肾是一种配备有复杂传感器阵列的多功能过滤装置。 对于人和小鼠的适当生理功能，肾脏必须大量排列，并且在其胎儿发育期间确定了定义肾脏的基本结构性。 该综述探讨了胎儿肾脏在胎儿肾脏的过程，概述了该领域的基础文学以及探索了该动态研究区域的新发展。 确保从小初始祖细胞组成大量肾的机制是该过程的核心，以及肾子祖细胞群余额如何与祖先的祖先的肾上腺素分化是特定的主题 兴趣。 讨论了关键生长因子信号传导途径和转录因子网络。

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