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首页> 外文期刊>Antiviral chemistry & chemotherapy >Efficacy of orally administered low dose N-methanocarbathymidine against lethalherpes simplex virus type-2 infections of mice.
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Efficacy of orally administered low dose N-methanocarbathymidine against lethalherpes simplex virus type-2 infections of mice.

机译：口服给药低剂量N-甲基疗法对小鼠替代替代病毒型2型感染的疗效。

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摘要

BACKGROUND: N-methanocarbathymidine (N-MCT) has previously been shown to beeffective against lethal orthopoxvirus and herpes simplex virus type-1 infectionsin mice. In this investigation, the antiviral activity of N-MCT was assessedagainst herpes simplex virus type-2 (HSV-2) in BALB/c mice.METHODS: BALB/c mice were infected intranasally with a lethal challenge dose ofHSV-2. N-MCT was administered orally twice daily to mice using doses of 0.01 to100 mg/kg to determine effects on survival and on viral replication in organ and central nervous system (CNS) samples.RESULTS: N-MCT provided significant protection from mortality even whentreatments were delayed until 3 days after viral infection. Viral replication in organ and CNS samples from N-MCT-treated mice was reduced below the limit ofdetection after 4 days of treatment.CONCLUSIONS: These results indicated that low dose N-MCT treatment was moreeffective than acyclovir therapy. N-MCT may be effective against HSV disease inhumans and is currently undergoing preclinical evaluation. In particular, itspotential use as a combination therapy for HSV, with its differing metabolismfrom acyclovir, make it a promising compound to develop for human use.
机译：背景：N-Methanocarbathymidine（N-MCT）先前已被证明对抗致死的致命性正交和疱疹病毒类型-1型感染蛋白小鼠。在该研究中，N-MCT的抗病毒活性是BALB / C小鼠中的SimberedABAinst疱疹病毒型-2（HSV-2）。方法：BALB / C小鼠用致死的攻击剂量ONHSV-2感染。 N-MCT每天口服给药两次，使用0.01-100mg / kg的小鼠测定对器官和中枢神经系统（CNS）样本的生存和病毒复制的影响延迟到病毒感染后3天。器官和来自N-MCT处理的小鼠的CNS样品中的病毒复制降低了4天后的限制下降。结论：这些结果表明，低剂量N-MCT治疗比Acyclovir治疗融化了。 N-MCT可能对HSV病不人道有效，目前正在进行临床前评估。特别地，其作为HSV的组合治疗的趋势用途，其不同的代谢来自Acyclovir，使其成为人类使用的有希望的化合物。

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