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首页> 外文期刊>Archives of Physical Medicine and Rehabilitation >Longitudinal description of the glasgow outcome scale-extended for individuals in the traumatic brain injury model systems national database: A national institute on disability and rehabilitation research traumatic brain injury model systems study
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Longitudinal description of the glasgow outcome scale-extended for individuals in the traumatic brain injury model systems national database: A national institute on disability and rehabilitation research traumatic brain injury model systems study

机译：Glasgow结果的纵向描述为创伤性脑损伤模型系统国家数据库中的个体延长：国家残疾和康复研究所创伤性脑损伤模型系统研究

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Objective To comprehensively describe the temporal patterns of global outcome after traumatic brain injury (TBI) in the Traumatic Brain Injury Model Systems National Database (TBIMS NDB). Design Longitudinal prospective cohort study. Setting TBI Model Systems centers. Participants Patients (N=3870) ≥16 years of age with moderate or severe TBI enrolled in the TBIMS NDB. Interventions None. Main Outcome Measure Glasgow Outcome Scale-Extended (GOS-E). Results The trajectory of the GOS-E scores is best described with a model of quadratic change, in which scores initially increase and peak approximately 10 years after the first GOS-E assessment, and then decrease. Change occurs most rapidly in the initial and final years of the timeline. There was significant variability in each growth parameter (P<.05). A reduced multilevel model was built, including all covariates (age at first GOS-E assessment, FIM, race, sex, rehabilitation length of stay) that related significantly to the growth parameters. An interactive tool was created to generate individual level trajectories based on various combinations of covariate values. Results provide an individual level account of the chronological progression of TBI outcomes, as measured by the GOS-E. Conclusions Individual growth curve analysis is a statistically rigorous approach to describe temporal change with respect to the GOS-E at the individual level for participants within the TBIMS NDB. Results indicated that, for individuals in the TBIMS NDB as a group, functional status as measured by the GOS-E initially improves, plateaus, and then begins to decline. Factors such as age at first GOS-E assessment, race, FIM score at rehabilitation admission, and rehabilitation length of stay were found to influence baseline GOS-E scores, as well as the rate and extent of both improvement and decline over time. Additional research may be required to determine the generalizability of these findings and the usefulness of this tool for clinical applications.
机译：目的在创伤性脑损伤模型系统国家数据库（TBIMS NDB）中，全面描述全球结果后全球结果的时间模式。设计纵向队列研究。设置TBI模型系统中心。参与者患者（N = 3870）≥16岁，中度或严重的TBI注册了TBIMS NDB。干预没有。主要结果测量格拉斯哥结果缩放（GOS-E）。结果GOS-E分数的轨迹最好用二次变化模型描述，其中分数最初在第一个GOS-E评估后大约10年增加，然后减少。在时间表的初始和最后几年中，更改会发生变化。每个生长参数（P <0.05）中存在显着的变化。建造了减少的多级模型，包括所有协变量（第一次GOS-e评估，FIM，种族，性别，康复长度的年龄），其与增长参数有关。创建一个交互式工具，以基于协变量值的各种组合生成单个级轨迹。结果提供了由GOS-E衡量的TBI结果的按时间顺序进展的个体级别账户。结论个体增长曲线分析是一种统计上严格的方法，用于描述TBIMS NDB内的参与者的个人级别的GOS-E的时间变化。结果表明，对于TBIMS NDB中的个体作为组的个体，由GOS-E测量的功能状态最初改善，平稳，然后开始下降。在康复招待中的第一个GOS-e评估，种族，FIM评分等因素发现，以及康复留下的康复时间，以及随着时间的推移和随着时间的推移的改善和衰退的速度和程度。可能需要进行额外的研究来确定这些发现的概括性和临床应用该工具的有用性。

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