Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines

Shen Qiming; Wang Haoyou; Zhang Lin

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Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines

机译：外源P51A基因对人肺腺癌细胞生长和化疗敏感性的影响

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Background: The dysfunction of p53-mediated apoptosis is the key to tumorigenesis, so most gene therapy programs concentrate on improving the expressing level of wild-type p53 in tumour cells. However, the p53 gene therapy has not yielded satisfactory results in tumours with normal p53 function. A new member of p53 gene family-p63, has provided new hopes. TAp63 gamma (p51A) resembles p53 the most, thus it might become a new promising therapeutic gene of tumours.

机译：背景：P53介导的细胞凋亡的功能障碍是肿瘤发生的关键，因此大多数基因治疗程序集中在改善肿瘤细胞中野生型P53的表达水平。然而，P53基因治疗在具有正常P53功能的肿瘤中尚未产生令人满意的结果。 P53基因家庭P63的新成员提供了新的希望。 Tap63 Gamma（P51a）最像p53，因此可能成为肿瘤的新有前途的治疗基因。

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《Artificial cells, nanomedicine, and biotechnology.》 |2018年第3期|共6页
作者
Shen Qiming; Wang Haoyou; Zhang Lin;
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作者单位

China Med Univ Shenyang Liaoning Peoples R China;

China Med Univ Shenyang Liaoning Peoples R China;

China Med Univ Shenyang Liaoning Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医用一般科学;
关键词
p51A gene; lung adenocarcinoma; gene therapy; chemotherapy; apoptosis;

机译：p51a基因;肺腺癌;基因治疗;化疗;细胞凋亡;

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1. p73基因对人肺腺癌细胞H1299化疗敏感性的影响 [J] . 何勇, 范士志, 蒋耀光, 癌症（英文版） . 2004,第006期
2. Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines [J] . Qiming Shen, Haoyou Wang, Lin Zhang Artificial cells, nanomedicine, and biotechnology. . 2018,第Suppa3期

机译：外源性p51a基因对人肺腺癌细胞生长和化学敏感性的影响
3. Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins [J] . William W. Lockwood, Kreshnik Zejnullahu, James E. Bradner, Proceedings of the National Academy of Sciences of the United States of America . 2012,第47期

机译：人肺腺癌细胞系对BET表观遗传信号蛋白靶向抑制的敏感性
4. Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors [J] . Justin M Balko, Anil Potti, Christopher Saunders, BMC Genomics . 2006,第1期

机译：预测肺癌细胞系和人肺肿瘤对表皮生长因子受体酪氨酸激酶抑制剂敏感性的基因表达模式
5. High fluence laser irradiation induces reactive oxygen species generation in human lung adenocarcinoma cells [C] . Fang Wang, Da Xing, Tong-Sheng Chen International Conference on Photonics and Imaging in Biology and Medicine . 2006

机译：高通量激光辐照诱导人肺腺癌细胞中活性氧的产生
6. Gene expression analysis of human non -small cell lung cancer subtypes, adenocarcinoma and squamous cell carcinoma, and mouse lung epithelial cell lines: Implications in lung tumorigenesis [D] . Silvers, Amy Lynn. 2002

机译：人类非小细胞肺癌亚型，腺癌和鳞状细胞癌以及小鼠肺上皮细胞系的基因表达分析：在肺肿瘤发生中的意义
7. MiR-21/PTEN signaling modulates the chemo-sensitivity to 5-fluorouracil in human lung adenocarcinoma A549 cells [O] . Shengguang Ding, Yifan Zheng, Yiming Xu, 2019

机译：MiR-21 / PTEN信号传导调节人肺腺癌A549细胞对5-氟尿嘧啶的化学敏感性
8. Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines [O] . Qiming Shen, Haoyou Wang, Lin Zhang 2018

机译：外源P51A基因对人肺腺癌细胞生长和化疗敏感性的影响
9. Identification of Genes Mediating Chemo-Sensitivity in Human Mammary Cells [R] . Haines, D. 2000

机译：鉴定介导人乳腺细胞化学敏感性的基因

Effect of exogenous p51a gene on the growth and chemo sensitivity of human lung adenocarcinoma cell lines

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