...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Arthritis and Rheumatism >Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population
【24h】

Effects of Smoking and Shared Epitope on the Production of Anti-Citrullinated Peptide Antibody in a Japanese Adult Population

机译：吸烟和共用表位对日本成年人群中抗瓜粉肽抗体生产的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective. Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) are markers to rheumatoid arthritis (RA). Smoking and shared epitope (SE) in HLA-DRBl are associated with the production of these autoantibodies in RA. Detailed distribution and characterization of ACPA and RF in the general population have remained unclear. We aimed to evaluate positivity of ACPA and RF in a general Japanese population and to detect correlates, including genetic components. Methods. ACPA and RF were quantified in 9,804 Japanese volunteers ages 30-75 years. Logistic regression analyses were performed to evaluate the effects of candidates of correlates on the autoantibody positivity. A genome-wide association study (GWAS) was performed using 394,239 single nucleotide polymorphisms for 3,170 participants, and HLA-DRBl alleles were imputed based on the GWAS data. Results. A total of 1.7% and 6.4% of subjects were positive for ACPA and RF, respectively, and the 2 markers showed a significant correlation (P = 2.0 X 10~-23). Old age was associated with ACPA positivity (P = 0.00062). Sex, smoking, SE, and other candidates of correlates did not have significant effects. Interaction between smoking and SE positivity was not apparent, but smoking showed a significant association with high levels of ACPA (P = 0.0019). Conclusion. ACPA and RF could be detected in 1.7% and 6.4% of the Japanese adult population without RA, respectively. ACPA and RF were suggested to share mechanisms even in healthy populations. Old age was associated with increasing ACPA positivity. While positivity of ACPA and RF was not associated with SE and smoking, an association between high ACPA and smoking was observed.
机译：客观的。抗瓜氨酸肽抗体（ACPA）和类风湿因子（RF）是对类风湿性关节炎（RA）的标志物。 HLA-DRBL中的吸烟和共用表位（SE）与RA中的这些自身抗体的产生有关。一般人群ACPA和RF的详细分布和表征仍不清楚。我们旨在评估ACPA和RF在日本一般人群中的阳性，并检测包括遗传组分的相关性。方法。 ACPA和RF量化在30-75岁的日本志愿者9,804岁。进行逻辑回归分析以评估相关性对自身抗体积极性的影响。使用394,239个单核苷酸多态性进行3,170名参与者进行基因组关联研究（GWAs），并且基于GWAS数据施加HLA-DRBL等位基因。结果。总共1.7％和6.4％的受试者分别对ACPA和RF呈阳性，2个标记显示出显着的相关性（P = 2.0×10〜-23）。晚年与ACPA阳性有关（P = 0.00062）。性，吸烟，SE和其他相关候选者没有显着影响。吸烟和SE阳性之间的相互作用并不明显，但吸烟表现出与高水平的ACPA有显着关联（P = 0.0019）。结论。 ACPA和RF分别可以分别以1.7％和6.4％的日本成年人群检测到没有RA的1.7％和6.4％。建议ACPA和RF甚至在健康人群中分享机制。年龄与增加的ACPA积极性有关。虽然ACPA和RF的阳性与SE和吸烟无关，但观察到高ACPA和吸烟之间的关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号