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首页> 外文期刊>Arthritis and Rheumatism >Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive lyme arthritis
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Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive lyme arthritis

机译：抗生素难治性或抗生素响应性百婚关节炎患者的Treg细胞数和功能

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摘要

Objective. In a murine model of antibiotic-refractory Lyme arthritis, the numbers of Treg cells are dramatically reduced. The aim of this study was to examine Treg cell numbers and function in patients with antibiotic-refractory Lyme arthritis. Methods. CD4+ T cell subsets were enumerated in the peripheral blood (PB) and synovial fluid (SF) of 12 patients with antibiotic-refractory arthritis and 6 patients with antibiotic-responsive arthritis. Treg cell function was examined using Borrelia-specific and nonspecific Treg cell proliferation assays. Results. In both patient groups, interferon-γ- positive Th1 cells in SF were abundant and enriched (～50% of CD4+ T cells). In patients with antibiotic-refractory arthritis, the median percentages of FoxP3-positive Treg cells were significantly higher in SF than in PB (12% versus 6%; P = 0.03) or in SF from patients with antibiotic-responsive arthritis (12% versus 5%; P = 0.04). Moreover, in the antibiotic-refractory group, a higher percentage of Treg cells in SF correlated with a shorter duration until resolution of arthritis (r = - 0.74, P = 0.006). In contrast, patients with fewer Treg cells had suboptimal responses to disease-modifying antirheumatic drugs and a longer duration of arthritis after antibiotic treatment, and they often required synovectomies for arthritis resolution. In each group, Treg cells in SF dampened Borrelia burgdorferi-specific proliferative responses, and in 2 patients with antibiotic-refractory arthritis, Treg cells were functional in nonspecific suppression assays. Conclusion. Treg cells were functional in patients with antibiotic-refractory arthritis, and in some patients, higher numbers of these cells in SF appeared to participate in arthritis resolution. However, as in the murine model, patients with antibiotic-refractory arthritis and lower numbers of Treg cells seemed unable to achieve resolution of synovial inflammation.
机译：客观的。在抗生素 - 难治性百婚关节炎的小鼠模型中，Treg细胞的数量显着降低。该研究的目的是检查Treg细胞数和抗生素 - 难治性百婚关节炎患者的功能。方法。在12例抗生素 - 难治性关节炎患者的外周血（PB）和滑膜液（SF）中列举了CD4 + T细胞亚群，6例抗生素响应性关节炎患者。使用Borrelia特异性和非特异性Treg细胞增殖测定检查Treg细胞功能。结果。在两个患者组中，SF中的干扰素-γ-阳性Th1细胞丰富并富集（〜50％的CD4 + T细胞）。在抗生素 - 难治性关节炎的患者中，SF中的FoxP3阳性Treg细胞的中位数百分比显着高于Pb（12％与6％; p = 0.03）或来自抗生素响应性关节炎患者的SF（12％与5％; p = 0.04）。此外，在抗生素 - 难治性基团中，在SF中具有较高百分比的Treg细胞与较短的持续时间相关，直到静脉炎分离（R = - 0.74，p = 0.006）。相比之下，Treg细胞较少的患者对抗生素治疗后的疾病修饰的抗尿剂药物和较长的关节炎持续时间具有次优应对，并且它们通常需要对关节炎分辨率的肖像术。在每组中，SF湿润的Borrelia Burgdorferi特异性增殖反应的Treg细胞，并且在2例抗生素 - 难治性关节炎患者中，Treg细胞在非特异性抑制测定中具有功能性。结论。 Treg细胞在抗生素 - 难治性关节炎的患者中是功能性的，并且在一些患者中，SF中的这些细胞较多似乎参与关节炎分辨率。然而，如在小鼠模型中，患有抗生素 - 难治性关节炎和较低数量的Treg细胞似乎无法实现滑膜炎症的分辨率。

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  • 来源
    《Arthritis and Rheumatism》 |2010年第7期|共11页
  • 作者

    ShenS.; ShinJ.J.; StrleK.; McHughG.; LiX.; GlicksteinL.J.; DrouinE.E.; SteereA.C.;

  • 作者单位

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

    Harvard Medical School Massachusetts General Hospital Boston MA United States;

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  • 正文语种 eng
  • 中图分类 免疫性疾病;
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