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首页> 外文期刊>Artificial Organs >A Physiological Controller for Turbodynamic Ventricular Assist Devices Based on Left Ventricular Systolic Pressure
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A Physiological Controller for Turbodynamic Ventricular Assist Devices Based on Left Ventricular Systolic Pressure

机译：基于左心室收缩压的土壤动力室内辅助装置的生理控制器

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摘要

The current article presents a novel physiological feedback controller for turbodynamic ventricular assist devices (tVADs). This controller is based on the recording of the left ventricular (LV) pressure measured at the inlet cannula of a tVAD thus requiring only one pressure sensor. The LV systolic pressure (SP) is proposed as an indicator to determine the varying perfusion requirements. The algorithm to extract the SP from the pump inlet pressure signal used for the controller to adjust the speed of the tVAD shows robust behavior. Its performance was evaluated on a hybrid mock circulation. The experiments with changing perfusion requirements were compared with a physiological circulation and a pathological one assisted with a tVAD operated at constant speed. A sensitivity analysis of the controller parameters was conducted to identify their limits and their influence on a circulation. The performance of the proposed SP controller was evaluated for various values of LV contractility, as well as for a simulated pressure sensor drift. The response of a pathological circulation assisted by a tVAD controlled by the introduced SP controller matched the physiological circulation well, while over- and underpumping events were eliminated. The controller presented a robust performance during experiments with simulated pressure sensor drift.
机译：本文提出了一种用于Turboynamic心室辅助设备（TVAD）的新型生理反馈控制器。该控制器基于在TVAD的入口套管处测量的左心室（LV）压力的记录，从而仅需要一个压力传感器。提出了LV收缩压（SP）作为确定不同灌注要求的指示剂。该算法从用于控制器的泵入口压力信号中提取SP以调节TVAD的速度，显示了鲁棒行为。它的性能是在混合模拟循环的情况下评估。将灌注要求改变的实验与生理循环进行比较，并且有助于以恒定速度操作的有线电视的病理。进行了对控制器参数的灵敏度分析，以识别它们对循环的限制及其影响。评估所提出的SP控制器的性能，用于LV收缩性的各种值，以及模拟压力传感器漂移。由引入的SP控制器控制的TVAD辅助的病理循环的响应良好地匹配了生理循环，同时消除了过度和疏松的事件。控制器在模拟压力传感器漂移的实验期间呈现了稳健的性能。

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