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首页> 外文期刊>Autophagy >Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections
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Autophagy plays an important role in protecting Pacific oysters from OsHV-1 and Vibrio aestuarianus infections

机译:自噬在于保护太平洋牡蛎免受奥什韦-1和vibrio Aestuarianus感染的重要作用

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摘要

Recent mass mortality outbreaks around the world in Pacific oysters, Crassostrea gigas, have seriously affected the aquaculture economy. Although the causes for these mortality outbreaks appear complex, infectious agents are involved. Two pathogens are associated with mass mortality outbreaks, the virus ostreid herpesvirus 1 (OsHV-1) and the bacterium Vibrio aestuarianus. Here we describe the interactions between these 2 pathogens and autophagy, a conserved intracellular pathway playing a key role in innate immunity. We show for the first time that autophagy pathway is present and functional in Pacific oysters and plays an important role to protect animals from infections. This study contributes to better understand the innate immune system of Pacific oysters.
机译:最近在太平洋牡蛎周围世界各地的大众死亡率爆发,严重影响了水产养殖经济。 虽然这些死亡率爆发的原因出现了复杂的感染者。 两种病原体与大规模死亡率爆发有关,病毒鸵鸟疱疹病毒1(oshv-1)和细菌vibrio aestuaryus。 在这里,我们描述了这两种病原体和自噬之间的相互作用,一种保守的细胞内途径在先天免疫力中发挥着关键作用。 我们首次展示了自噬途径在太平洋牡蛎中存在和功能,并发挥重要作用以保护动物免受感染。 这项研究有助于更好地了解太平洋牡蛎的天生免疫系统。

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