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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Fertility treatment, twin births, and unplanned pregnancies in women with eating disorders: Findings from a population-based birth cohort
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Fertility treatment, twin births, and unplanned pregnancies in women with eating disorders: Findings from a population-based birth cohort

机译：饮食失调妇女的生育治疗，双胞胎和计划外怀孕：基于人群的出生队列的发现

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Objective: To investigate fertility treatment, twin births, and unplanned pregnancies in pregnant women with eating disorders in a population-based sample. Design: A longitudinal population-based birth cohort (Generation R). Setting: Rotterdam, the Netherlands. Sample: Women from the Generation R study who reported a history of (recent or past) anorexia nervosa (n = 160), bulimia nervosa (n = 265), or both (n = 130), and a history of psychiatric disorders other than eating disorders (n = 1396) were compared with women without psychiatric disorders (n = 4367). Methods: Women were compared on the studied outcomes using logistic regression. We performed crude and adjusted analyses (adjusting for relevant confounding factors). Main outcome measures: Fertility treatment, twin births, unplanned pregnancies, and women's feelings towards unplanned pregnancies. Results: Relative to women without psychiatric disorders, women with bulimia nervosa had increased odds (odds ratio, OR, 2.3; 95% confidence interval, 95% CI, 1.1-5.2) of having undergone fertility treatment. Women with all eating disorders had increased odds of twin births (anorexia nervosa, OR 2.7, 95% CI 1.0-7.7; bulimia nervosa, OR 2.7, 95% CI 1.1-6.6; anorexia and bulimia nervosa, OR 3.795% CI 1.3-10.7). Anorexia nervosa was associated with increased odds of unplanned pregnancies (OR 1.8, 95% CI 1.2-2.6) and mixed feelings about these pregnancies (adjusted OR 5.0, 95% CI 1.7-14.4). Pre-pregnancy body mass index did not explain the observed associations. Conclusions: Eating disorders are associated with increased odds of receiving fertility treatment and twin births. Women with anorexia nervosa were more likely to have an unplanned pregnancy and have mixed feelings about the unplanned pregnancy. Fertility treatment specialists should be aware that both active and past eating disorders (both anorexia nervosa and bulimia nervosa) might underlie fertility problems.
机译：目的：在以人群为基础的样本中，研究饮食失调的孕妇的生育治疗，双胞胎和计划外怀孕。设计：基于人口的纵向出生队列（R代）。地点：荷兰鹿特丹。样本：R一代研究中的女性，报告了（最近或过去）神经性厌食症（n = 160），神经性贪食症（n = 265）或两者（n = 130）的病史，以及除以下以外的精神疾病史将进食障碍（n = 1396）与没有精神病的妇女（n = 4367）进行比较。方法：使用逻辑回归对妇女的研究结果进行比较。我们进行了粗略的和经过调整的分析（针对相关的混杂因素进行了调整）。主要结果指标：生育治疗，双胞胎，计划外怀孕以及妇女对计划外怀孕的感觉。结果：相对于没有精神疾病的妇女，神经性贪食症的妇女接受生育治疗的几率（优势比，OR，2.3; 95％置信区间，95％CI，1.1-5.2）。所有饮食失调的妇女双胞胎的几率增加（神经性厌食症，OR 2.7，95％CI 1.0-7.7;神经性贪食症，OR 2.7，95％CI 1.1-6.6;神经性厌食症和神经性贪食症，OR 3.795％CI 1.3-10.7 ）。神经性厌食症与计划外怀孕的机率增加（OR 1.8，95％CI 1.2-2.6）和对这些怀孕的喜忧参半（校正后的OR 5.0，95％CI 1.7-14.4）相关。孕前体重指数不能解释观察到的关联。结论：饮食失调与接受生育治疗和双胞胎的机会增加有关。神经性厌食症的妇女更有可能进行计划外的怀孕，并对计划外的怀孕有不同的感觉。生育治疗专家应注意，既往活动和既往饮食失调（神经性厌食症和神经性贪食症）均可能是生育问题的根源。

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