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首页> 外文期刊>Annual Review of Immunology >Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes
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Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

机译：对蠕虫的免疫：抗胃肠线虫的抵抗力，调节和易感性

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摘要

Helminth parasites are a highly successful group of pathogens that challenge the immune system in a manner distinct from rapidly replicating infectious agents. Of this group, roundworms (nematodes) that dwell in the intestines of humans and other animals are prevalent worldwide. Currently, more than one billion people are infected by at least one species, often for extended periods of time. Thus, host-protective immunity is rarely complete. The reasons for this are complex, but laboratory investigation of tractable model systems in which protective immunity is effective has provided a mechanistic understanding of resistance that is characterized almost universally by a type 2/T helper 2 response. Greater understanding of the mechanisms of susceptibility has also provided the basis for defining host immunoregulation and parasite-evasion strategies, helping place in context the changing patterns of immunological disease observed worldwide.
机译：Helminth Parasites是一组高度成功的病原体，以与快速复制传染病的方式挑战免疫系统。 在这个群体中，围绕人类和其他动物肠道的蛔虫（线虫）在全世界普遍存在。 目前，超过10亿人被至少一个物种感染，通常是延长的一段时间。 因此，宿主保护性免疫很少完成。 这是复杂的原因，但对保护豁免是有效的贸易模型系统的实验室调查提供了对抗性的机械理解，其几乎普遍地由类型2 / T辅助2响应。 更加了解易感性机制也为定义了宿主免疫调节和寄生虫逃号的基础，帮助地在全世界观察到的免疫疾病变化模式。

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