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首页> 外文期刊>Indian journal of physiology and pharmacology >SPECTRAL ANALYSIS OF HEART RATE VARIABILITY IN BRONCHIAL ASTHMA PATIENTS
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SPECTRAL ANALYSIS OF HEART RATE VARIABILITY IN BRONCHIAL ASTHMA PATIENTS

机译：支气管哮喘患者心率变异的光谱分析

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Abstract : The study was carried in the Departments of Physiology and Medicine at S.M.S. Medical College, Jaipur. Thirty patients of bronchial asthma, aged 20-30 years attending outpatient clinics of S.M.S. Hospital and thirty healthy volunteers were recruited in the present study for spectral analysis of Heart Rate Variability (HRV) using impedance peripheral pulse in the right forearm. Two spectral components were recorded namely high frequency (HF) component (0.15-0.4 Hz), an indicator of vagal efferent activity and low frequency (LF) component (0.04-0.15 Hz), replicator of composite sympatho-vagal interplay. These components were analyzed as LF nu (Low Frequency normalized unit), HF nu (High Frequency normalized unit) and LF/HF ratio. Low frequency component in absolute units of the asthmatic patients differed insignificantly (P>0.05) from LF of the subjects, whereas the same calculated as normalized units was found to be significantly low in the patient group (P<0.01), as compared to that of the control group. The High Frequency (in absolute units) index of HRV was significantly high in asthmatics (P<0.01) as compared to the HF (absolute units) of controls. Similar trend was observed in the normalized units of HF (P<0.01). LF/HF ratio was not significantly different in patient and control groups (P>0.05). It was concluded that a significantly raised central vagal outflow and a concomitant significantly low central sympathetic efferent could be appreciated in asymptomatic asthmatic patients as compared to that in the control group. This deranged sympathovagal interplay with parasympathetic dominance could be a plausible pathophysiological mechanism leading to airway obstruction, the hallmark of bronchial asthma.
机译：摘要：该研究在S.M.S的生理和医学部门进行。斋浦尔医学院。三十岁的支气管哮喘患者，年龄在20-30岁以下的星期间诊所。在本研究中招募了医院和三十个健康的志愿者，用于使用右前臂中的阻抗外周脉冲对心率变异性（HRV）的光谱分析。记录了两种光谱分量，即高频（HF）组分（0.15-0.4Hz），迷进活性和低频（LF）组分（0.04-0.15Hz）的指示，复合综合迷离相互作用的复制器。将这些组分分析为LF NU（低频归一化单元），HF NU（高频归一化单元）和LF / HF比率。哮喘患者的绝对单位的低频分量从受试者的LF差异不大（p> 0.05），而发现患者组中的标准化单位相同的计算值得明显低（P <0.01），相比对照组。与对照的HF（绝对单位）相比，HRV的高频（绝对单位）指数在哮喘症中显着高（P <0.01）。在HF的标准化单位中观察到类似的趋势（P <0.01）。患者和对照组的LF / HF比没有显着差异（P> 0.05）。结论是，与对照组相比，在无症状哮喘患者中，可以理解显着升高的中央迷进流出和伴随的中央交感神经发生器。这种具有副交感神经统治性的紊乱的同性恋相互作用可能是一种可符号的病理生理机制，导致气道阻塞，支气管哮喘的标志。

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