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首页> 外文期刊>Internal medicine journal >Urolithiasis is associated with an increased risk of stroke: a population‐based 5‐year follow‐up study
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Urolithiasis is associated with an increased risk of stroke: a population‐based 5‐year follow‐up study

机译：尿道病与中风的风险增加有关：基于人群的5年后续研究

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Abstract Background Epidemiological studies have reported an association between urolithiasis and cardiovascular disease. However, studies examining the risks of ischaemic and haemorrhagic stroke in patients with urolithiasis are limited. Aims and methods By using a nationwide population database, we conducted a matched cohort study to investigate the association between urolithiasis and longitudinal risks of ischaemic and haemorrhagic stroke. Results The urolithiasis and non‐urolithiasis cohorts included 12 979 and 64 895 patients respectively. Of these, 728 (5.6%) and 2802 (4.3%) patients in the urolithiasis and non‐urolithiasis cohorts, respectively, had a stroke during the 5‐year follow‐up period. The hazard ratio (HR) for stroke was 1.19 times higher (95% confidence interval [CI] = 1.10–1.29; P 0.001) in the urolithiasis cohort than in the non‐urolithiasis cohort after adjustment for potential confounders. The risk of both ischaemic (adjusted HR = 1.16; 95% CI = 1.05–1.29) and haemorrhagic stroke (adjusted HR = 1.30; 95% CI = 1.03–1.64) remained significant in the urolithiasis cohort. Furthermore, the risk of stroke was significant in both men (adjusted HR = 1.16; 95% CI = 1.05–1.28) and women (adjusted HR = 1.26; 95% CI = 1.10–1.45). Middle‐aged (40–59 years; adjusted HR = 1.26; 95% CI = 1.10–1.45) and older (≥60 years; adjusted HR = 1.14; 95% CI = 1.03–1.27) patients had a particularly high risk of stroke. Conclusions The present study detected an increased risk of both ischaemic and haemorrhagic stroke in patients with urolithiasis, particularly in those older than 40 years.
机译：摘要背景流行病学研究报道了尿道病和心血管疾病之间的关联。然而，研究尿道病患者患者缺血性和出血性脑卒中风险的研究有限。目的和方法通过使用全国范围的人口数据库，我们进行了一项匹配的队列研究，以研究尿道病和缺血性和出血性卒中纵向风险之间的关联。结果分别包括12 979和64个895名患者的尿道病和非尿石病队列。其中728（5.6％）和2802名（4.3％）分别在尿道病和非尿道病队列中，在5年的随访期间患有中风。中风的危险比（HR）较高1.19倍（95％置信区间= 1.10-1.29; p <0.001），而不是在调节潜在混凝剂后的非尿石病毒队列中。缺血的风险（调整后的HR = 1.16; 95％CI = 1.05-1.29）和出血性卒中（调节的HR = 1.30; 95％CI = 1.03-1.64）在尿道病队列中仍然显着。此外，两种男性中风的风险很大（调节的HR = 1.16; 95％CI = 1.05-1.28）和女性（调整后的HR = 1.26; 95％CI = 1.10-1.45）。中年（40-59岁;调整后的HR = 1.26; 95％CI = 1.10-1.45）和较大（≥60岁;调整后的HR = 1.14; 95％CI = 1.03-1.27）患者的中风风险特别高。结论本研究检测到尿道病患者患者缺血性和出血性脑卒中的风险增加，特别是在40岁以上的患者中。

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