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首页> 外文期刊>International immunopharmacology >BAY 41-2272 inhibits human T lymphocyte functions
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BAY 41-2272 inhibits human T lymphocyte functions

机译：Bay 41-2272抑制人类T淋巴细胞功能

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BAY 41-2272 increases guanosine 3', 5'-cyclic monophosphate (cGMP) levels by stimulating soluble guanylate cyclase (sGC). In this study, we evaluated the effect of BAY 41-2272 on human T lymphocyte functions. Pretreating T cells for 24 h with BAY 41-2272 at 3 mu M and 30 mu M, followed by activation with 90 nM phorbol myristate acetate (PMA), inhibited interferon-gamma (IFN-gamma) production, with 3 mu M and 30 mu M BAY causing 16.5-fold and 12.1-fold inhibition, respectively, compared to PMA alone (p < 0.05, one-way ANOVA followed by Tukey's test). We also observed suppressive effects on the expression of CD69, with 30 mu M BAY causing 3.55-fold lower expression than PMA/ionomycin (p < 0.001 one-way ANOVA followed by Tukey's test), and T-bet, with 30 mu M BAY causing 1.47-fold lower expression than PMA/ionomycin (p < 0.05, one-way ANOVA test followed by Tukey's test). Additionally, T lymphocyte proliferation was reduced 2.13-fold and 4.3-fold, respectively, by 3 mu M BAY and 30 mu M BAY compared to PMA/ionomycin (p < 0.01, p < 0.001, one-way ANOVA followed by Tukey's test). BAY 41-2272 inhibits human T lymphocyte function and may be explored as an immunomodulatory drug in patients with autoimmune/inflammatory diseases and lymphoproliferative syndromes.
机译：托架41-2272通过刺激可溶性胍基环化酶（SGC）增加鸟苷3'，5'-环状单磷酸（CGMP）水平。在这项研究中，我们评估了海湾41-2272对人T淋巴细胞功能的影响。预处理T细胞24小时，30μm和30μm的海湾41-2272，随后用90nm Phorbol myristate醋酸酯（PMA）激活，抑制干扰素-γ（IFN-Gamma）的生产，3亩m和30与单独的PMA相比，MU M海湾分别导致16.5倍和12.1倍的抑制（P <0.05，单向ANOVA，然后是TUKEY测试）。我们还观察到抑制对CD69表达的抑制作用，30μm湾引起3.55倍的表达比PMA /离子霉素（P <0.001单向ANOVA，然后是Tukey的测试），以及30亩湾引起比PMA /离子霉素更低的​​表达1.47倍（P <0.05，单向ANOVA测试，然后是Tukey的测试）。另外，与PMA /离子霉素相比，T淋巴细胞增殖分别降低了2.13倍和4.3倍，30μm湾（P <0.01，P <0.001，单向ANOVA，随后Tukey测试） 。托架41-2272抑制人体T淋巴细胞功能，可作为自身免疫/炎症性疾病和淋巴抑制性综合征患者中的免疫调节药物探索。

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