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首页> 外文期刊>International immunopharmacology >Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma
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Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma

机译：氧化气道炎症导致过敏性哮喘的小鼠模型中的系统性和血管氧化应激

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Oxidant-antioxidant imbalance plays an important role in repeated cycles of airway inflammation observed in asthma. It is when reactive oxygen species (ROS) overwhelm antioxidant defenses that a severe inflammatory state becomes apparent and may impact vasculature. Several studies have shown an association between airway inflammation and cardiovascular complications; however so far none has investigated the link between airway oxidative stress and systemic/vascular oxidative stress in a murine model of asthma. Therefore, this study investigated the contribution of oxidative stress encountered in asthmatic airways in modulation of vascular/systemic oxidant-antioxidant balance. Rats were sensitized intraperitoneally with ovalbumin (OVA) in the presence of aluminum hydroxide followed by several intranasal (i.n.) challenges with OVA. Rats were then assessed for airway and vascular inflammation, oxidative stress (ROS, lipid peroxides) and antioxidants measured as total antioxidant capacity (TAC) and thiol content. Challenge with OVA led to increased airway inflammation and oxidative stress with a concomitant increase in vascular inflammation and oxidative stress. Oxidative stress in the vasculature was significantly inhibited by antioxidant treatment, N-acetyl cysteine; whereas hydrogen peroxide (H2O2) inhalation worsened it. Therefore, our study shows that oxidative airway inflammation is associated with vascular/systemic oxidative stress which might predispose these patients to increased cardiovascular risk. (c) 2015 Elsevier B.V. All rights reserved.
机译：氧化剂 - 抗氧化不平衡在哮喘观察到的气道炎症的反复循环中起重要作用。正是当反应性氧物种（ROS）压倒抗氧化剂的抗氧化剂防御时，严重的炎症状态变得明显，可能会影响脉管系统。几项研究显示了气道炎症和心血管并发症之间的关联;然而，到目前为止，没有研究哮喘小鼠模型中的气道氧化应激和全身/血管氧化应激之间的联系。因此，本研究调查了哮喘呼吸道遇到的氧化应激在调节血管/全身氧化剂 - 抗氧化剂平衡中的贡献。大鼠在氢氧化铝存在下用卵烧蛋（OVA）腹膜内敏化，然后用OVA挑战几种鼻内（I.N.）挑战。然后评估大鼠的气道和血管炎症，氧化应激（ROS，脂质过氧化物）和测量作为总抗氧化能力（TAC）和硫醇含量的抗氧化剂。 OVA挑战导致气道炎症和氧化胁迫增加，伴随血管炎症和氧化应激。通过抗氧化处理，N-乙酰半胱氨酸显着抑制脉管系统中的氧化应激;虽然过氧化氢（H 2 O 2）吸入摩擦。因此，我们的研究表明，氧化气道炎症与血管/全身氧化应激有关，可能使这些患者能够提高心血管风险。 （c）2015 Elsevier B.v.保留所有权利。

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