Helix pomatia hemocyanin - A novel bio-adjuvant for viral and bacterial antigens

Gesheva Vera; Chausheva Stela; Stefanova Nadia; Mihaylova Nikolina; Doumanova Lyuba; Idakieva Krassimira; Tchorbanov Andrey

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Helix pomatia hemocyanin - A novel bio-adjuvant for viral and bacterial antigens

机译：Helix Pomatia Hemocyanin - 病毒和细菌抗原的新型生物佐剂

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Background: New generated subunit vaccines are characterized by increased safety and lack of side effects, however they suffer from weak immunogenicity. The adjuvants are substances that have the ability to enhance the magnitude and duration of the immune response and to increase vaccine efficacy, but the different vaccines may require diverse adjuvants. The urgent need of novel adjuvant formulations occurs, thus ensuring protective cellular and humoral responses against infectious pathogens.

机译：背景：新生成的亚基疫苗的特征在于增加安全性和缺乏副作用，但它们患有弱免疫原性。佐剂是具有增强免疫应答的幅度和持续时间的能力和增加疫苗疗效的物质，但不同的疫苗可能需要各种佐剂。发生新的佐剂制剂的迫切需要，从而确保了对传染病的保护性细胞和体液反应。

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来源
《International immunopharmacology》 |2015年第1期|共7页
作者
Gesheva Vera; Chausheva Stela; Stefanova Nadia; Mihaylova Nikolina; Doumanova Lyuba; Idakieva Krassimira; Tchorbanov Andrey;
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作者单位

Bulgarian Acad Sci Inst Microbiol Expt Immunol Lab BU-1113 Sofia Bulgaria;

Bulgarian Acad Sci Inst Microbiol Expt Immunol Lab BU-1113 Sofia Bulgaria;

Bulgarian Acad Sci Inst Microbiol Expt Immunol Lab BU-1113 Sofia Bulgaria;

Bulgarian Acad Sci Inst Microbiol Expt Immunol Lab BU-1113 Sofia Bulgaria;

Bulgarian Acad Sci Inst Microbiol Expt Immunol Lab BU-1113 Sofia Bulgaria;

Bulgarian Acad Sci Inst Organ Chem BU-1113 Sofia Bulgaria;

Bulgarian Acad Sci Inst Microbiol Expt Immunol Lab BU-1113 Sofia Bulgaria;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Bio-adjuvants; Vaccines; Gastropodan hemocyanins; Helix pomatia; Immunological modulators;

机译：生物佐剂;疫苗;胃胃血红素血红蛋白;螺旋Pomatia;免疫调节剂;

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专利

1. Helix pomatia hemocyanin - A novel bio-adjuvant for viral and bacterial antigens [J] . Gesheva Vera, Chausheva Stela, Stefanova Nadia, International immunopharmacology . 2015,第1期

机译：Helix pomatia血蓝蛋白-病毒和细菌抗原的新型生物佐剂
2. Involvement of glycans in the immunological cross-reaction between α-macroglobulin and hemocyanin of the gastropod Helix pomatia [J] . Nurul I. Siddiqui, Yinges Yigzaw, Gisele Preaux, Biochimie . 2009,第4期

机译：聚糖参与腹足动物螺旋体果肉α-巨球蛋白与血蓝蛋白之间的免疫交叉反应
3. Thermal stability of homologous functional units of Helix pomatia hemocyanin does not correlate with carbohydrate content. [J] . Yesilyurt BT, Gielens C, Meersman F The FEBS journal . 2008,第14期

机译：螺旋果血红蛋白的同源功能单元的热稳定性与碳水化合物含量不相关。
4. Engineered Artificial Micro-organism Expressing Antigen as a Novel Vaccine against Viral/Bacterial Infections [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：将抗原的设计人工微生物作为针对病毒/细菌感染的新疫苗
5. IMMUNE CAPABILITIES OF THE ZEBRAFISH, BRACHYDANIO RERIO (HAMILTON-BUCHANAN): I. IMMUNE RESPONSE TO VIRAL, ERYTHROCYTE AND BACTERIAL ANTIGENS. II. EFFECT OF SUBLETHAL DOSES OF ZINC ON THE IMMUNERESPONSE TO VIRAL AND BACTERIAL ANTIGENS. [D] . SAROT, DANIEL ARTHUR. 1973

机译：斑马鱼，布拉迪达尼奥·雷里奥（HAMILTON-BUCHANAN）的免疫能力：I.对病毒，红细胞和细菌抗原的免疫反应。二。锌的剂量对病毒和细菌抗原的免疫反应的影响。
6. Herpes simplex virus type-selective enzyme-linked immunosorbent assay with Helix pomatia lectin-purified antigens. [O] . B Svennerholm, S Olofsson, S Jeansson, 1984

机译：用螺旋螺旋体凝集素纯化的抗原进行单纯疱疹病毒类型选择酶联免疫吸附试验。
7. Binding of carbon-monoxide to Alpha-Hemocyanin and Beta-Hemocyanin from Helix-pomatia [O] . Kuiper, Harry A., Torensma, Ruurd, Van Bruggen, Ernst J. 1976

机译：一氧化碳与螺旋果树的α-血红素和β-血红素的结合

Helix pomatia hemocyanin - A novel bio-adjuvant for viral and bacterial antigens

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