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首页> 外文期刊>International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience >Role of the endocannabinoid system in neurological disorders
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Role of the endocannabinoid system in neurological disorders

机译：Endocannabinoid系统在神经障碍中的作用

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摘要

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that begins in infancy. Although the etiology and pathogenesis are poorly understood, many studies have shown that ASD is closely related to structural and functional defects in the nervous system, especially synaptic transmission. The endocannabinoid (eCB) system is an important regulatory system of the central nervous system that regulates neurotransmission and synaptic plasticity and plays an important role in emotional and social responses and cognitive function. The relationship between eCB system and ASD has attracted increasing attention from scholars. In this review, we discuss the complex lipid signaling network of the eCB system, intracellular transport pathways, abnormal expression and association with various neurological diseases, and direct and indirect evidence for the link between eCB and ASD. Collectively, the findings to date indicate that the eCB system plays a key role in the pathophysiology of ASD and can provide new insights into potential interventions and rehabilitation strategies for ASD.
机译：自闭症谱系障碍（ASD）是初期开始的复杂神经发育障碍。虽然病因和发病机制较差，但许多研究表明，ASD与神经系统中的结构和功能缺陷密切相关，尤其是突触传递。 Endocannabinoid（ECB）系统是中枢神经系统的重要调节系统，调节神经递血和突触可塑性，并在情感和社会反应和认知功能中起着重要作用。欧洲央行系统与ASD之间的关系吸引了学者的越来越关注。在本文中，我们讨论了ECB系统的复杂脂质信号网络，细胞内传输途径，异常表达和与各种神经疾病的关联，以及欧洲央行和ASD之间的联系的直接和间接证据。迄今为止，调查结果表明，欧洲央行系统在亚委员会的病理生理学中发挥着关键作用，并可以为亚摩式的潜在干预和康复战略提供新的见解。

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