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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models
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Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models

机译：基于当前实践和疗效模型的治疗热疗临床施用磁流体临床和临床前剂量限制的评述

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摘要

We offer a critique of what constitutes a suitable dosage limit, in both clinical and preclinical studies, for interstitially administered magnetic nanoparticles in order to enable therapeutic hyperthermia under the action of an externally applied alternating magnetic field. We approach this first from the perspective of the currently approved clinical dosages of magnetic nanoparticles in the fields of MRI contrast enhancement, sentinel node detection, iron replacement therapy and magnetic thermoablation. We compare this to a simple analytical model of the achievable hyperthermia temperature rise in both humans and animals based on the interstitially administered dose, the heating and dispersion characteristics of the injected fluid, and the strength and frequency of the applied magnetic field. We show that under appropriately chosen conditions a therapeutic temperature rise is achievable in clinically relevant situations. We also show that in such cases it may paradoxically be harder to achieve the same therapeutic temperature rise in a preclinical model. We comment on the implications for the evidence-based translation of hyperthermia based interventions from the laboratory to the clinic.
机译：在临床施用的磁性纳米颗粒中，我们提供了对临床和临床前研究构成合适的剂量限制的批评，以便在外部施加的交替磁场的作用下实现治疗热疗。从MRI对比度增强的磁性纳米粒子的目前批准的临床剂量的角度来看，我们首先接近这一点，Sentinel节点检测，熨斗替代治疗和磁热能。我们将其与基于透孔施用剂量，注射流体的加热和分散特性以及所施加的磁场的强度和频率的可实现的体育和动物可实现的热疗升高的简单分析模型。 We show that under appropriately chosen conditions a therapeutic temperature rise is achievable in clinically relevant situations.我们还表明，在这种情况下，它可能矛盾地难以在临床前模型中实现相同的治疗温度升高。我们评论了从实验室到诊所的基于循证干预措施的循证转化的影响。

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