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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients
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The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients

机译：脑显微化的分布决定了它们与非心脏栓塞急性中风患者的动脉僵硬的关联

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Background and purpose: Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type. Whether the presence and location of CMBs are associated with brachial-ankle pulse wave velocity (baPWV) which represents a measure of arterial stiffness was investigated. Methods: Between June 2006 and January 2012, 1137 consecutive patients diagnosed with non-cardioembolic acute ischaemic stroke and who underwent baPWV measurement and brain gradient-echo imaging were enrolled. CMBs were classified as deep or infratentorial or strictly lobar according to their location. Severity of leukoaraiosis was determined using the Fazekas scoring system. Results: CMBs were found in 30.7% of the included patients. These patients were older than those without CMBs. Mean baPWV was higher in patients with CMBs than in those without (20 ± 5 m/s vs. 19 ± 5 m/s; P = 0.001). When comparing baPWV according to the location of the CMB, it was higher in the deep or infratentorial CMB group than in the strictly lobar CMB group (22 ± 5 m/s vs. 20 ± 5 m/s; P = 0.001). In univariate and multivariate multinomial logistic regression analyses, baPWV was found to be independently associated with deep or infratentorial CMBs. Conclusions: Arterial stiffness was independently associated with deep or infratentorial CMBs but not lobar CMBs. These findings suggest a pathophysiological association between arterial stiffness and CMBs in the deep or infratentorial region.
机译：背景和目的：增加的动脉僵硬导致血管损伤在最终器官中。因此，大脑中的小血管可能易于增加动脉僵硬。脑微斑秃（CMBS）正在拓扑或病理物理学上分类为深或Infratential类型和严格的洛洛型。 CMBS的存在和位置是否与臂踝脉搏波速度（BAPWV）相关联，该脉冲波速度（BAPWV）表示研究了动脉刚度的量度。方法：2006年6月至2012年1月，1137名连续患者诊断出非心脏栓塞急性缺血性脑卒中，并注册了接受BAPWV测量和脑梯度 - 回声成像的患者。根据他们的位置，CMBS被归类为深或基础或严格的洛加。利用Fazekas评分系统确定了菌落病的严重程度。结果：CMBS占包括患者的30.7％。这些患者比没有CMBS的患者年龄大。 CMBS患者的平均bapWV比没有（20±5 m / s与19±5 m / s; p = 0.001）的患者更高。根据CMB的位置比较BaPWV，在深层或Infratentorial CMB组中比严格的瓣CMB组更高（22±5 m / s与20±5 m / s; p = 0.001）。在单变量和多变量多元逻辑回归分析中，发现BAPWV与深或Infratental CMBS独立相关。结论：动脉刚度与深或基础CMBS独立相关，但不是瓣CMBS。这些发现表明，深或基础区域中的动脉僵硬和CMBS之间的病理生理学结合。

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