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Coeliac disease: further evidence that biopsy is not always necessary for diagnosis

机译:乳糜泻:进一步证据表明活检并不总是需要诊断

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Objectives Growing evidence supports the view that the diagnosis of coeliac disease (CD) can be made by serological tests alone, although this approach is still not widely accepted. We previously showed in retrospective and prospective studies that in adults an IgA-tissue transglutaminase antibody cut-off can be defined above which the positive predictive value for CD is 100%. Following a change in the analytical method for measuring the antibody, our objectives were to re-examine this finding in a larger series of adults to ascertain whether a diagnosis of CD can be reliably made in a proportion of patients without the need for small bowel biopsy and to re-evaluate the diagnostic guidelines used in our centre.
机译:目的越来越多的证据支持乳糜泻(CD)的诊断可以通过血管疾病(CD)单独制备,尽管仍未被广泛接受这种方法。 之前,我们以备注和前瞻性研究表明,在成年人中,可以定义IGA组织转谷氨酰胺酶抗体截止值,以上,CD的阳性预测值为100%。 在测量抗体的分析方法的变化之后,我们的目标是在更大系列的成年人中重新检查这一发现,以确定是否可以在没有需要小肠活检的情况下可靠地制成CD的诊断 并重新评估我们中心使用的诊断指南。

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