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Management of Hypersensitivity Reactions to Taxanes

机译:管理对紫杉烷的过敏反应

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摘要

Taxanes are an important class of antineoplastic agents used in the treatment of a wide variety of cancers. However, paclitaxel and docetaxel, which are the most commonly used taxanes, elicit immediate hypersensitivity reactions (HSRs) in 5% to 10% of patients. Almost all patients that experience these reactions can be safely re-exposed to taxanes either through desensitization or challenge. This article describes the clinical presentation, diagnosis, and management of HSRs to taxanes and discusses the different options for their safe readministration.
机译:紫杉烷是一种重要的抗肿瘤剂,用于治疗各种癌症。 然而,紫杉醇和多西紫杉醇是最常用的紫杉烷,引发了直接过敏反应(HSRS)5%至10%的患者。 几乎所有经历这些反应的患者都可以通过敏化或挑战安全地将其安全地重新暴露于紫杉烷。 本文介绍了HSRS到紫杉烷的临床演示,诊断和管理,并讨论了他们的安全书籍的不同选择。

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