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首页> 外文期刊>Experimental and therapeutic medicine >Application of silk fibroin/chitosan/nano-hydroxyapatite composite scaffold in the repair of rabbit radial bone defect
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Application of silk fibroin/chitosan/nano-hydroxyapatite composite scaffold in the repair of rabbit radial bone defect

机译：丝纤维蛋白/壳聚糖/纳米羟基磷灰石复合支架在兔径向骨缺损修复中的应用

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摘要

Silk fibroin (SF), chitosan (CS) and nanohydroxyap-atite (nHA) possess excellent biocompatibility, thus, these were used to construct a SF/CS/nHA composite scaffold. Previously published results identified that this material exhibited satisfactory physical and chemical properties, and therefore qualified as a repair material in bone tissue engineering. The aim of the present study was to investigate the capacity and mechanism of this composite scaffold in repairing bone defects. In total, 45 New Zealand white rabbits were used to model defect in the right radial bone. A radial bone defect was induced, and rabbits were divided into the following treatment groups (n=15 in each): Group A, in which the SF/CS/nHA scaffold was implanted; group B, in which the SF/CS scaffold was implanted; and group C, in which rabbits did not receive subsequent treatment. X-ray scanning, specimen observation and histopathological examination were implemented at 1, 2, 3 and 4 months after modeling, in order to evaluate the osteogenic capacity and mechanism. At 1 month after modeling, the bone density shadow in the X-ray scan was darker in group A as compared with that in group B. Observation of the pathological specimens indicated that normal bone tissues partially replaced the scaffold. At 2 months, the bone density shadow of group A was similar to normal bone tissues, and normal tissue began to replace the scaffold. At 3-4 months after modeling, the X-ray scan and histopathological observation indicated that the normal bone tissues completely replaced the scaffold in group A, with an unobstructed marrow cavity. However, the bone mass of group B was lower in comparison with that of group A. The bone defect induced in group C was filled with fibrous connective tissues. Therefore, it was concluded that the SF/CS/nHA composite scaffold may be a promising material for bone tissue engineering.
机译：丝素蛋白（SF），壳聚糖（CS）和纳米羟基涂覆atite（NHA）具有优异的生物相容性，因此，这些用于构建SF / Cs / NHA复合支架。以前公布的结果确定该材料表现出令人满意的物理和化学性质，因此符合骨组织工程中的修复材料。本研究的目的是探讨该复合支架在修复骨缺陷方面的能力和机制。共有45个新西兰白兔用于模拟右径向骨骼的缺陷。诱导径向骨缺损，兔子分为以下处理基团（各自的N = 15）：A组，其中植入SF / Cs / NHA支架; B组，其中植入SF / CS支架;和C组，其中兔子没有接受随后的治疗。 X射线扫描，样本观察和组织病理学检查在建模后的1,2,3和4个月内实施，以评估成骨能力和机制。在建模1个月后，与B组中，X射线扫描中的骨密度阴影在A组中较暗。观察病理标本表明正常骨组织部分更换支架。在2个月时，A组的骨密度阴影类似于正常的骨组织，并且正常组织开始取代支架。在建模后3-4个月，X射线扫描和组织病理学观察表明，正常骨组织完全取代了A组中的支架，具有无阻碍的骨髓腔。然而，与A组α的骨骨质量较低。C组中诱导的骨缺损填充有纤维状结合组织。因此，得出结论是SF / CS / NHA复合支架可以是骨组织工程的有希望的材料。

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