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首页> 外文期刊>Expert review of vaccines >Advancing community stakeholder engagement in biomedical HIV prevention trials: Principles, practices and evidence
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Advancing community stakeholder engagement in biomedical HIV prevention trials: Principles, practices and evidence

机译：推进社区利益相关者参与生物医学艾滋病毒预防审判：原则，做法和证据

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摘要

Community stakeholder engagement is foundational to fair and ethically conducted biomedical HIV prevention trials. Concerns regarding the ethical engagement of community stakeholders in HIV vaccine trials and early terminations of several international pre-exposure prophylaxis trials have fueled the development of international guidelines, such as UNAIDS' good participatory practice (GPP). GPP aims to ensure that stakeholders are effectively involved in all phases of biomedical HIV prevention trials. We provide an overview of the six guiding principles in the GPP and critically examine them in relation to existing social and behavioral science research. In particular, we highlight the challenges involved in operationalizing these principles on the ground in various global contexts, with a focus on low-income country settings. Increasing integration of social science in biomedical HIV prevention trials will provide evidence to advance a science of community stakeholder engagement to support ethical and effective practices informed by local realities and sociocultural differences.
机译：社区利益攸关方参与是基础，是公平和道德进行的生物医学艾滋病毒预防试验。关于社区利益攸关方在艾滋病毒疫苗试验中的伦理参与的担忧以及几次国际预防预防审判的早期终止促进了国际准则的发展，例如艾滋病规划署的良好参与者实践（GPP）。 GPP旨在确保利益相关者有效地参与生物医学艾滋病毒预防试验的所有阶段。我们概述了GPP中的六项指导原则，并批判性地审查了与现有的社会和行为科学研究相关。特别是，我们突出了在各种全球背景下在地面上运作这些原则所涉及的挑战，重点是低收入国家环境。增加生物医学艾滋病毒预防审判中社会科学的整合将提供有证据，以推进社区利益相关者参与的科学，以支持当地的现实和社会文化差异了解的道德和有效的做法。

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