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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans
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Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans

机译：中药提取物的纯化合物对六口念珠菌种类的有效抗真菌活性和氟康唑对抗唑抗性的念珠菌念珠菌的协同作用

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摘要

This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis, and Candida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjogren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six Candida spp, and to isolates from HIV-negative, HIV-positive, and Sjogren's syndrome patients. The MIC values ranged from 16 to 128 mug/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.
机译：本研究旨在评估四种中药（TCM）提取物的体外抗真菌活性。使用标准盘扩散和肉汤微量稀释试验评估假脯氨酸B，牙龈蛋白，莱茵和林氏和Hation的抑制作用。他们测试了六种口头念珠菌物种，念珠菌，念珠菌，念珠菌，念珠菌，念珠菌，念珠菌，Candida，念珠菌，包括来自HIV阴性，艾滋病毒阳性和Sjogren综合征患者的临床分离物。发现假脯氨酸B具有最有效的抗真菌效果，并且向所有六个念珠菌SPP显示出类似的抗真菌活性，并与HIV阴性，艾滋病毒阳性和Sjogren综合征患者分离。麦克风值范围为16至128麦克风/ ml。更有意义地，观察到伪脯氨酸B与氟康唑组合的协同作用。我们认为假脯氨酸B可能是治疗口腔念珠菌病的潜在治疗杀菌剂。

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