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Guselkumab for the treatment of psoriasis

机译：Guselkumab用于治疗牛皮癣

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Introduction: Psoriasis is a chronic immune mediated disease in which the interplay of T cells and keratinocytes seems to play a key role. In this context, the interleukin (IL)-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis and the selective inhibition of IL-23 may be viewed as an improvement of treatments blocking both IL-23 and IL-12, since its upstream actions. Areas covered: The authors performed a thorough and updated review on guselkumab, a fully human IgG1?monoclonal antibody that blocks the p19 subunit of IL-23, analyzing efficacy and safety data from phase I, II and III trials. Expert opinion: Guselkumab represents a very promising therapy, providing an alternative mechanism of action with high efficacy and safety profiles, sustained total skin clearance, and rapid onset of effect also to psoriasis patients who previously failed or experienced an inadequate response to anti-TNF-?or anti-IL12/23. Guselkumab will definitively shift therapeutic goals of psoriasis management from PASI 75 to PASI 90 and 100 due to its exciting trials results, also favored by its increased treatment adherence due to its administering regimen (100 mg injection at week 0, 4 and then every 8 weeks).
机译：介绍：牛皮癣是一种慢性免疫介导的疾病，其中T细胞和角质形成细胞的相互作用似乎发挥着关键作用。在这种情况下，白细胞介素（IL）-23 / IL-17轴当前认为在牛皮癣的发病机制中是至关重要的，并且可以将IL-23的选择性抑制视为阻断IL-23和IL的治疗的改善-12，自上游行动以来。所涵盖的区域：作者对Guselkumab进行了彻底和更新的审查，一种全人IgG1？单克隆抗体，其阻断IL-23的P19亚基，分析来自I阶段I，II和III试验的疗效和安全数据。专家意见：Guselkumab代表着非常有前景的治疗，提供了具有高疗效和安全性的替代动作机制，持续全屏清除，并且对先前失败或经历对抗TNF不足或经历不足反应的牛皮癣患者的快速发作。 ？或抗IL12 / 23。由于其令人兴奋的试验结果，Guselkumab将从PASI 75转向PASI 75至PASI 90和100的牛皮癣管理的治疗目标。由于其施用方案（每周0,4，然后每8周，每8周内100毫克注射100毫克注射，也赞成其增加的治疗依从性。 ）。

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