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Gene therapy for hypertension

机译：基因治疗高血压

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Introduction: The control of hypertension and the resulting cardiovascular events is still insufficient. Thus, the search for novel means for blood pressure (BP) reduction remains worth further clinical and research attention. The advances in vector and construct design sketch the use of gene therapy in hypertension.Areas covered: We have searched for studies using gene therapy in hypertension reporting BP outcomes. We have identified 63 experimental studies demonstrating feasible targeting of the classical and new renin-angiotensin-aldosterone system, 1-adrenergic receptor, NO-cGMP axis, endothelin, natriuretic peptides, kallikrein system, cytochrome P-450 hydroxylase, oncogenes, growth factors, interleukins, angiopoietin-1, adrenomedullin or Klotho in small rodents.Expert opinion: The usual BP reduction was by 10-30mmHg for up to several months. Some studies reported target organ damage attenuation or even survival prolongation. However, the concept did not reach the clinical phase, in contrast to other cardiovascular conditions. Increased gene transfection efficacy necessary for a systemic treatment, personalized identification of the implied aetiology from the multifactorial background and evidence from larger mammals are required for gene therapy to compete with the broad spectrum of current therapeutic options in hypertension. Until then, in the field of hypertension, gene modulation will provide a valuable research tool.
机译：引言：高血压控制和所产生的心血管事件仍然不足。因此，寻求新颖的血压（BP）减少手段仍然值得进一步临床和研究关注。向量和构建设计草图的进步利用基因疗法在高血压中的使用。覆盖：我们已经搜索了使用基因治疗在高血压中的研究报告BP结果。我们已经确定了63项实验研究，证明了古典和新的血管紧张素 - 醛固酮系统，1-肾上腺素受体，No-CGMP轴，内皮素，利钠肽，Kallikrein系统，细胞色素P-450羟化酶，癌基因，生长因子， Interleukins，血管发成素-1，肾上腺素髓质素或小啮齿动物中的klotho.expert意见：通常的BP减少率为10-30mmHg，高达几个月。一些研究报告了靶器官损伤衰减甚至存活延长。然而，与其他心血管条件相比，该概念没有达到临床阶段。系统治疗所需的基因转染效果增加，基因疗法需要从多因素背景和来自较大哺乳动物的证据的个性化鉴定，以与高血压中的广谱竞争激光的热疗法。直到于期，在高血压领域，基因调制将提供有价值的研究工具。

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