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Immunotherapy for the treatment of breast cancer

机译：免疫疗法治疗乳腺癌

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Introduction: Breast cancer is the most common cancer as well as the first cause of death by cancer in women worldwide. Although routine treatment improves the outcome of early stage breast cancer patients, there is no effective therapy for the disseminated disease. Immunotherapy has emerged as a powerful therapeutic strategy for the treatment of many cancers. Although traditionally conceived as a non-immunogenic tumor, breast cancer is now considered a potential target for immunotherapy.Areas covered: In this review, the authors discuss different immunotherapeutic strategies that are currently being tested for the treatment of breast cancer: These strategies include: (i) blockade of immunological checkpoints, (ii) antitumor vaccines, (iii) regulatory T cell blockade, (iv) adoptive T cell transfer therapy, (iv) adoptive immunotherapy with monoclonal antibodies, and (v) combination of immunotherapy with chemotherapy.Expert opinion: A growing body of evidence indicates that immunotherapeutic strategies can benefit a larger cohort of breast cancer patients than hitherto anticipated. Since breast tumors entail multiple mechanisms to impair antitumor immunity, the immunological characterization of individual tumors and the selection of suitable combinations of chemotherapeutic and immunotherapeutic approaches are required to achieve significant clinical benefit in these patients.
机译：介绍：乳腺癌是最常见的癌症以及癌症在全球癌症的第一个死亡原因。虽然常规治疗改善了早期乳腺癌患者的结果，但没有有效的散发疾病治疗。免疫疗法已成为治疗许多癌症的强大治疗策略。虽然传统上认为是一种非免疫原性肿瘤，但乳腺癌现在被认为是免疫疗法的潜在目标。在本综述中，作者讨论了目前正在测试的不同免疫治疗策略，用于治疗乳腺癌：这些策略包括： （i）阻断免疫检查点，（ii）抗肿瘤疫苗，（iii）调节性T细胞α障碍，（IV）采用T细胞转移治疗，（IV）用单克隆抗体的养殖免疫治疗，（v）与化疗的免疫疗法组合。专家意见：越来越多的证据表明免疫治疗策略可以使较大的乳腺癌患者群体受益于预期。由于乳腺肿瘤需要多种机制来损害抗肿瘤免疫力，因此需要各种肿瘤的免疫表征以及选择合适的化学治疗和免疫治疗方法的组合来实现这些患者的显着临床益处。

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