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Directional coupling of oligodendrocyte connexin-47 and astrocyte connexin-43 gap junctions

机译：oligodendrocyte connexin-47和星形胶质细胞连接蛋白-33间隙连接的定向偶联

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摘要

Intercellular communication via gap junction channels between oligodendrocytes and between astrocytes as well as between these cell types is essential to maintain the integrity of myelin in the central nervous system. Oligodendrocyte gap junction connexin-47 (Cx47) is a key element in this crosstalk and indeed, mutations in human Cx47 cause severe myelin disorders. However, the permeation properties of channels of Cx47 alone and in heterotypic combination with astrocyte Cx43 remain unclear. We show here that Cx47 contains three extra residues at 5 ' amino-terminus that play a critical role in the channel pore structure and account for relative low ionic conductivity, cationic permselectivity and voltage-gating properties of oligodendrocyte-oligodendrocyte Cx47 channels. Regarding oligodendrocyte-astrocyte coupling, heterotypic channels formed by Cx47 with Cx43 exhibit ionic and chemical rectification, which creates a directional diffusion barrier for the movement of ions and larger negatively charged molecules from cells expressing Cx47 to those with Cx43. The restrictive permeability of Cx47 channels and the diffusion barrier of Cx47-Cx43 channels was abolished by a mutation associated with leukodystrophy, the Cx47P90S, suggesting a novel pathogenic mechanism underlying myelin disorders that involves alterations in the panglial permeation.
机译：通过寡突胶质细胞和星形胶质细胞之间的间隙连接通道以及这些细胞类型之间的间细胞间通信对于保持中枢神经系统中髓鞘的完整性至关重要。 oligodendrocyte nap结connectin-47（cx47）是这种串扰中的关键元素，实际上，人cx47中的突变导致严重的髓鞘紊乱。然而，单独CX47和与星形胶质细胞CX43的异质组合的渗透性质仍不清楚。在此显示CX47在5'氨基末端中包含三个额外的残留物，在通道孔结构中发挥着关键作用，并考虑了少突胶细胞 - 少突突罗基脲CX47通道的相对低离子电导率，阳离子渗滤性和电压门 - 门静脉。关于少突胶质细胞 - 星形胶质细胞偶联，CX47与CX43形成的异质通道表现出离子和化学精馏，其为离子运动和较大带负电荷分子的定向扩散屏障与CX43表达CX47的细胞和较大带负电的分子。 CX47通道的限制性渗透率和CX47-CX43通道的扩散屏障被CX47P90S相关的突变消除了突变，表明髓鞘疾病的新致病机制涉及牙龈渗透的改变。

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