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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Inconclusive results in preimplantation genetic testing: go for a second biopsy?
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Inconclusive results in preimplantation genetic testing: go for a second biopsy?

机译：遗传遗传学测试的不确定结果：去进行第二个活组织检查？

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The transition in biopsy timing from blastomere to trophectoderm biopsy has led to a remarkable decrease in the percentage of undiagnosed blastocysts. However, patients with few or no euploid blastocysts can be affected by this residual percentage of diagnosis failure. The aim of this study is to assess whether blastocyst rebiopsy and revitrification is an efficient and safe procedure to be applied in cases of no results after analysis. Fifty-three patients agreed to the warming of 61 blastocysts to perform a second biopsy and PGT-A by aCGH. Only 75.4% of the blastocysts survived, reexpanded, and could be rebiopsied. After the second biopsy and analysis, 95.6% of the blastocysts were successfully diagnosed with an euploidy rate of 65.9%. Eighteen euploid blastocysts were warmed and transferred to 18 patients with a 100% survival and reexpansion rate. Seven clinical pregnancies have been achieved with 4 live births, 1 ongoing pregnancy, and 2 miscarriages. Thus, although few transfers of rebiopsied and revitrified blastocysts have been performed till date, our preliminary results show that this approach is efficient and safe to be applied for undiagnosed blastocysts, as it ultimately allows the transfer of euploid blastocysts and good clinical outcomes.
机译：从卵泡到肾小管胚胎活检的活组织检查时序的过渡导致未确诊胚泡的百分比显着降低。然而，患有少倍骨囊胚囊的患者可能受到这种残留的诊断衰竭百分比的影响。本研究的目的是评估胚泡重生和重染性是否是在分析后没有结果的情况下应用的有效和安全的程序。五十三名患者同意加热61个骨囊，通过ACGH进行第二个活组织检查和PGT-A。只有75.4％的胚泡存活，重新纳入，可以重新植检。在第二次活检和分析后，95.6％的胚泡被成功诊断为每倍性率为65.9％。将十八欧倍体胚泡温热并转移至18名患者100％存活和再通环率。七个临床怀孕已经通过4个活产，1次持续怀孕，2个流产。因此，虽然迄今为止，虽然近期进行了较少的重新植物和复制胚泡的转移，但我们的初步结果表明这种方法是有效和安全的，以适用于未确诊的胚泡，因为它最终允许各种百倍胚泡和良好的临床结果转移。

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