MPP1-based mechanism of resting state raft organization in the plasma membrane. Is it a general or specialized mechanism in erythroid cells?

Trybus Magdalena; Niemiec Lukasz; Bineratowska Agnieszka; Hryniewicz-Jankowska Anita; Sikorski Aleksander F.

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MPP1-based mechanism of resting state raft organization in the plasma membrane. Is it a general or specialized mechanism in erythroid cells?

机译：基于MPP1的静态筏组织在血浆膜中的机制。它是红细胞细胞中的一般还是专用机制？

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Biological membranes are organized in various microdomains, one of the best known being called membrane rafts. The major function of these is thought to organize signaling partners into functional complexes. An important protein found in membrane raft microdomains of erythroid and other blood cells is MPP1 (membrane palmitoylated protein 1)/p55. MPP1 (p55) belongs to the MAGUK (membrane-associated guanylate kinase homolog) family and it is a major target of palmitoylation in the red blood cells (RBCs) membrane. The well-known function of this protein is to participate in formation of the junctional complex of the erythrocyte membrane skeleton. However, its function as a "raft organizer" is not well understood. In this review we focus on recent reports concerning MPP1 participation in membrane rafts organization in erythroid cells, including its role in signal transduction. Currently it is not known whether MPP1 could have a similar role in cell types other than erythroid lineage. We present also preliminary data regarding the expression level of MPP1 gene in several non-erythroid cell lines.

机译：生物膜以各种微膜组织，其中一种称为膜筏。这些主要功能被认为将信号合作伙伴组织成功能复合物。在膜筏微水面中发现的一个重要蛋白质和其他血细胞是MPP1（膜棕榈酰胺蛋白1）/ p55。 MPP1（P55）属于Maguk（膜相关的胍基激酶同源物）家族，它是红细胞（RBCS）膜中棕榈酸盐的主要目标。该蛋白质的众所周知的功能是参与形成红细胞膜骨架的结络合物。然而，它作为“筏组织者”的功能并不顺利。在本综述中，我们专注于最近关于MPP1参与膜筏组织在红细胞细胞中的报告，包括其在信号转导中的作用。目前尚不清楚MPP1是否可以在比红细胞谱系以外的细胞类型中具有相似的作用。我们还存在关于MPP1基因在几种非红细胞细胞系中的表达水平的初步数据。

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来源
《Folia histochemica et cytobiologica》 |2019年第2期|共13页
作者
Trybus Magdalena; Niemiec Lukasz; Bineratowska Agnieszka; Hryniewicz-Jankowska Anita; Sikorski Aleksander F.;
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作者单位

Univ Wroclaw Fac Biotechnol Dept Cytobiochem F Joliot Curie 14a PL-50383 Wroclaw Poland;

Univ Wroclaw Fac Biotechnol Dept Cytobiochem F Joliot Curie 14a PL-50383 Wroclaw Poland;

Univ Wroclaw Fac Biotechnol Dept Cytobiochem F Joliot Curie 14a PL-50383 Wroclaw Poland;

Univ Wroclaw Fac Biotechnol Dept Cytobiochem F Joliot Curie 14a PL-50383 Wroclaw Poland;

Univ Wroclaw Fac Biotechnol Dept Cytobiochem F Joliot Curie 14a PL-50383 Wroclaw Poland;

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正文语种 eng
中图分类细胞生物学;
关键词
membrane palmitoylated protein 1 (MPP1); resting state rafts; lateral membrane organization; raft-associated proteins;

机译：膜棕榈酰胺蛋白1（MPP1）;休息状态筏;侧膜组织;筏相关蛋白质;

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MPP1-based mechanism of resting state raft organization in the plasma membrane. Is it a general or specialized mechanism in erythroid cells?

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