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首页> 外文期刊>Frontiers in neuroendocrinology >The cerebellum under stress
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The cerebellum under stress

机译：压力下的小脑

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摘要

Stress-related psychiatric conditions are one of the main causes of disability in developed countries. They account for a large portion of resource investment in stress-related disorders, become chronic, and remain difficult to treat. Research on the neurobehavioral effects of stress reveals how changes in certain brain areas, mediated by a number of neurochemical messengers, markedly alter behavior. The cerebellum is connected with stress-related brain areas and expresses the machinery required to process stress-related neurochemical mediators. Surprisingly, it is not regarded as a substrate of stress-related behavioral alterations, despite numerous studies that show cerebellar responsivity to stress. Therefore, this review compiles those studies and proposes a hypothesis for cerebellar function in stressful conditions, relating it to stress-induced psychopathologies. It aims to provide a clearer picture of stress-related neural circuitry and stimulate cerebellum-stress research. Consequently, it might contribute to the development of improved treatment strategies for stress-related disorders.
机译：相关的精神病条件是发达国家残疾的主要原因之一。他们占对压力相关疾病的大部分资源投资，成为慢性，仍然难以治疗。对压力的神经表达效应的研究揭示了某些脑区域的变化，由许多神经化学信使介导的，显着改变行为。小脑与应力相关的脑区域连接，并表达处理应力相关的神经化学介质所需的机器。令人惊讶的是，尽管有许多研究表明对应激的急性反应性，但它​​不被视为与应激相关的行为改变的基质。因此，本评价汇总了这些研究，并提出了在压力条件下的小脑功能的假设，使其与应激诱导的精神病理学相关。它旨在提供更清晰的相关神经电路和刺激小脑压力研究的图片。因此，它可能有助于开发改进的相关疾病治疗策略。

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