Carbonic anhydrase activators

Supuran Claudiu T.

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Carbonic anhydrase activators

机译：碳酸酐酶激活剂

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Mammalian carbonic anhydrases (CAs; EC 4.2.1.1) of which 16 isoforms are known, are involved in important physiological functions. Their inhibition is exploited pharmacologically for the treatment of many diseases (glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, etc.) but the activators were less investigated till recently. A review on the CA activation is presented, with the activation mechanism, drug design approaches of activators and comparison of the various isoforms activation profiles being discussed. Some CAs, which are abundant in the brain, were recently demonstrated to be activatable by drug-like compounds, affording the possibility to design agents that enhance cognition, with potential therapeutic applications in aging and neurodegenerative diseases as well as tissue engineering.

机译：哺乳动物碳酸酐酶（CAS; EC 4.2.1.1），其中16种同种型是涉及重要的生理功能。它们的抑制在药理学上被药物治疗许多疾病（青光眼，水肿，癫痫，肥胖症，缺氧肿瘤，神经性疼痛等），但最近的活化剂较小。提出了关于CA激活的综述，具有激活机制，激活剂的药物设计方法以及正在讨论各种同种型活化型材的比较。最近在大脑中丰富的一些CAS通过类似药物化合物可激活，这是对增强认知的药剂的可能性，具有衰老和神经变性疾病以及组织工程的潜在治疗应用。

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来源
《Future medicinal chemistry》 |2018年第5期|共14页
作者
Supuran Claudiu T.;
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作者单位

Univ Firenze Sez Sci Farmaceut &

Nutraceut Dipartimento Neurofarba Via U Schiff 6 I-50019;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
activator; amine; amino acid; carbonic anhydrase; cognition enhancement; proton transfer;

机译：活化剂;胺;氨基酸;碳酸酐酶;认知增强;质子转移;

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1. Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators [J] . Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, Journal of enzyme inhibition and medicinal chemistry. . 2021,第1期

机译：氨基醇肟醚从人脑中激活碳酸酐酶：朝向人碳酸酐酶VII选择性活化剂
2. Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids. [J] . Innocenti A, Hall RA, Scozzafava Bioorganic and medicinal chemistry . 2010,第3期

机译：碳酸酐酶激活剂：用胺和氨基酸激活病原真菌白色念珠菌和新隐球菌的β-碳酸酐酶。
3. Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids. [J] . Innocenti A, Leewattanapasuk W, Manole G, Bioorganic and Medicinal Chemistry Letters . 2010,第5期

机译：碳酸酐酶激活剂：用胺和氨基酸激活病原酵母光滑念珠菌中的β-碳酸酐酶。
4. Role of Carbonic Anhydrase as an Activator in Carbonate Rock Dissolution and Its Implication for Atmospheric CO_2 Sink [C] . LIU Zaihua First International Conference on Sustainable Development in Karst Regions amp; International Working Group Meeting of IGCP 448 "World Correlation of Karst Ecosystems Aug 30-Sep 2, 2001 Beijing, P.R. China . 2001

机译：碳酸酐酶作为活化剂在碳酸盐岩溶解中的作用及其对大气CO_2汇的意义
5. (I) Zinc complexes as synthetic analogues for carbonic anhydrase and as catalysts for hydrogen production and carbon dioxide functionalization (II) Application of lithium silylamides in the synthesis of transition metal isocyanide compounds from their car [D] . Sattler, Wesley. 2012

机译：（I）锌配合物，可作为碳酸酐酶的合成类似物，并用作制氢和二氧化碳功能化的催化剂（II）甲硅烷基锂在其汽车合成过渡金属异氰化物中的应用
6. Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators [O] . Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, 2021

机译：氨基醇肟醚从人脑中激活碳酸酐酶：朝向人碳酸酐酶VII选择性活化剂
7. Structure and function of carbonic anhydrases Imidazole binding to human carbonic anhydrase B and the mechanism of action of carbonic anhydrases [O] . Kannan K.K., Petef M., Fridborg K., 1977

机译：碳酸酐酶的结构和功能咪唑与人碳酸酐酶B的结合以及碳酸酐酶的作用机理

Carbonic anhydrase activators

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