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MR-based respiratory and cardiac motion correction for PET imaging

机译：宠物成像先生的呼吸和心动校正

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Highlights ? PET motion correction from simultaneously acquired MR-derived motion model. ? Fast MR acquisition freeing scan time per PET bed for further diagnostic sequences. ? Clinically feasible setup: streamlined processing in Gadgetron evaluation on a cohort of 36 patients. ? Publicly available: https://sites.google.com/site/kspaceastronauts . Graphical abstract Display Omitted Abstract Purpose: To develop a motion correction for Positron-Emission-Tomography (PET) using simultaneously acquired magnetic-resonance (MR) images within 90?s. Methods: A 90?s MR acquisition allows the generation of a cardiac and respiratory motion model of the body trunk. Thereafter, further diagnostic MR sequences can be recorded during the PET examination without any limitation. To provide full PET scan time coverage, a sensor fusion approach maps external motion signals (respiratory belt, ECG-derived respiration signal) to a complete surrogate signal on which the retrospective data binning is performed. A joint Compressed Sensing reconstruction and motion estimation of the subsampled data provides motion-resolved MR images (respiratory + cardiac). A 1-POINT DIXON method is applied to these MR images to derive a motion-resolved attenuation map. The motion model and the attenuation map are fed to the Customizable and Advanced Software for Tomographic Reconstruction (CASToR) PET reconstruction system in which the motion correction is incorporated. All reconstruction steps are performed online on the scanner via Gadgetron to provide a clinically feasible setup for improved general applicability. The method was evaluated on 36 patients with suspected liver or lung metastasis in terms of lesion quantification (SUVmax, SNR, contrast), delineation (FWHM, slope steepness) and diagnostic confidence level (3-point Likert-scale). Results: A motion correction could be conducted for all patients, however, only in 30 patients moving lesions could be observed. For the examined 134 malignant lesions, an average improvement in lesion quantification of 22%, delineation of 64% and diagnostic confidence level of 23% was achieved. Conclusion: The proposed method provides a clinically feasible setup for respiratory and cardiac motion correction of PET data by simultaneous short-term MRI. The acquisition sequence and all reconstruction steps are publicly available to foster multi-center studies and various motion correction scenarios.
机译：强调 ？同时获取MR衍生运动模型的宠物运动校正。还快速先MR采集每只宠物床的扫描时间，以获得进一步的诊断序列。还临床可行的设置：在36名患者的队列上的Gadgetron评估中的简化处理。还公开可用：https://sites.google.com/site/kspaceastrons。图形摘要显示省略了抽象目的：在90°内的同时获取的磁共振（MR）图像同时获取正电子发射断层扫描（PET）的运动校正。方法：90？S MR采集允许生成身体躯干的心脏和呼吸运动模型。此后，可以在PET检查期间记录进一步的诊断MR序列，而无需任何限制。为了提供完整的PET扫描时间覆盖，传感器融合方法将外部运动信号（呼吸带，ECG衍生呼吸信号）映射到执行回读数据排列的完整代理信号。限制数据的关节压缩传感重建和运动估计提供了运动解析的MR图像（呼吸+心脏）。将1点Dixon方法应用于这些MR图像以导出运动解析的衰减图。运动模型和衰减图被馈送到可定制和高级软件，用于断层切断重建（蓖麻）宠物重建系统，其中包含运动校正。所有重建步骤都通过Gadgetron在扫描仪上在线执行，以提供临床可行的设置，以改善一般适用性。根据病变定量（SUVMAX，SNR，对比），描绘（FWHM，斜坡陡峭）和诊断置信水平（3点李克特级），对36例怀疑肝脏或肺转移进行评估该方法。结果：对于所有患者，可以进行运动校正，但只有在30例患者中，可以观察到移动病变。对于检测到的134个恶性病变，降噪量化的平均改善为22％，划分64％，诊断置信水平为23％。结论：该方法通过同时短期MRI提供呼吸系统呼吸和心动运动校正的临床可行设置。采集序列和所有重建步骤都公开可用于促进多中心研究和各种运动校正方案。

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