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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >Role of aryl hydrocarbon receptor in cancer
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Role of aryl hydrocarbon receptor in cancer

机译：芳烃受体在癌症中的作用

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Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely expressed in a variety of animal species and humans. Recent animal and human data suggested that AHR is involved in various signaling pathways critical to cell normal homeostasis, which covers multiple aspects of physiology, such as cell proliferation and differentiation, gene regulation, cell motility and migration, inflammation and others. Dysregulation of these physiological processes is known to contribute to events such as tumor initiation, promotion, and progression. Increasing epidemiological and experimental animal data provided substantial support for an association between abnormal AHR function and cancer, implicating AHR may be a novel drug-interfering target for cancers. The proposed underlying mechanisms of its actions in cancer involved multiple aspects, (a) inhibiting the functional expression of the key anti-oncogenes (such as p53 and BRCA1), (b) promoting stem cells transforming and angiogenesis, (c) altering cell survival, proliferation and differentiation by influencing the physiologic processes of cell-cycle, apoptosis, cell contact-inhibition, metabolism and remodel of extracellular matrix, and cell-matrix interaction, (d) cross-talking with the signaling pathways of estrogen receptor and inflammation. This review aims to provide a brief overview of recent investigations into the role of AHR and the underlying mechanisms of its actions in cancer, which were explored by the new technologies emerging in recent years.
机译：芳烃受体（AHR）是一种胞质配体激活的转录因子，属于bHLH / PAS异二聚体转录调节因子家族的成员，在多种动物和人类中广泛表达。最近的动物和人类数据表明，AHR参与了对细胞正常体内稳态至关重要的各种信号传导途径，涵盖了生理学的多个方面，例如细胞增殖和分化，基因调控，细胞运动性和迁移，炎症等。已知这些生理过程的失调促成诸如肿瘤起始，促进和进展的事件。越来越多的流行病学和实验动物数据为异常AHR功能与癌症之间的关联提供了实质性支持，这暗示AHR可能是癌症的一种新型药物干扰靶标。拟议的其在癌症中作用的潜在机制涉及多个方面，（a）抑制关键抗癌基因（例如p53和BRCA1）的功能表达，（b）促进干细胞转化和血管生成，（c）改变细胞存活率影响细胞周期，凋亡，细胞接触抑制，细胞外基质的代谢和重塑以及细胞-基质相互作用的生理过程的增殖和分化;（d）与雌激素受体和炎症的信号通路发生串扰。这篇综述旨在简要概述AHR在癌症中的作用及其作用的潜在机制，这是近年来新兴技术的探索。

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