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Tumors of Uncertain Differentiation

机译:不确定分化的肿瘤

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Intramuscular Myxoma: Intramuscular myxoma is a benign neoplasm arising within large muscles with a predilection for the thighs, buttocks, and the shoulders and upper arms. Myxomas usually occur in middle-aged or elderly patients and show a female predominance. Most myxomas are sporadic but there is a minor subset of myxomas which are occasionally multiple and associated with fibrous dysplasia (Mazabraud syndrome). A cellular myxoma is a variant of myxoma with increased cel-lularity and capillary vessels but without the cellular atypia observed in smears from low-grade myxofibrosarcoma. Jux-ta-articular myxoma is yet another variant of myxoma with similar cytomorphologic features but a different clinical presentation. They are most often seen near the knee. Both cellular myxomas and juxta-articular myxomas carry a risk of local recurrence in contrast to usual intramuscular myxomas that never recur after local excision. Smears from myxomas are hypocellular and contain loosely clustered or isolated spindle cells with small round to oval bland nuclei and long cytoplasmic processes in an abundant myxoid background [1-4] (Fig. 1). Fragments of capillaries are rare or absent. Scattered macrophages with cytoplasmic vacuoliza-tion may be seen in smears (Fig. 1).
机译:肌内肌瘤:肌肉内肌瘤是一种良性肿瘤,在大肌肉内产生,具有大腿,臀部和肩部和上臂的偏好。肌瘤通常发生在中年或老年患者中,表现出女性优势。大多数骨髓瘤是散发性的,但有一个少量肌瘤子集,偶尔偶尔和纤维发育不良(Mazabraud综合征)有关。细胞肌瘤是肌瘤的变体,肌唇疱疹增加,毛细血管血管增加,但没有从低级肌肌瘤的涂片中观察到的细胞非典型。 JUX-TA关节肌瘤是肌瘤的另一个变体,具有相似的细胞形态特征,但临床呈现。它们通常在膝盖附近看到。细胞肌瘤和Juxta关节肌瘤都患有局部复发的风险与通常在当地切除后永不反复的肌肉内肌瘤。来自肌瘤的涂片是间面的,并且含有松散的聚集或分离的主轴细胞,其小圆形到椭圆形蓝色的肌细胞和长细胞质过程中,在丰富的霉菌背景下[1-4](图1)。毛细血管的片段是罕见的或不存在的。具有细胞质染色液体的散射巨噬细胞可以在涂片中看到(图1)。

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