The mechanobiology of brain function.

William J Tyler

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The mechanobiology of brain function.

机译：大脑功能的力学学。

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All cells are influenced by mechanical forces. In the brain, force-generating and load-bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal signalling and plasticity. Although the functions of mechanosensitive proteins have been thoroughly described in classical sensory systems, the effects of endogenous mechanical energy on cellular function in the brain have received less attention, and many working models in neuroscience do not currently integrate principles of cellular mechanics. An understanding of cellular-mechanical concepts is essential to allow the integration of mechanobiology into ongoing studies of brain structure and function.

机译：所有细胞都受到机械力的影响。在大脑中，力产生和承重蛋白质扭曲，转动，棘轮，弯曲，压缩，膨胀和弯曲以介导神经元信号传导和可塑性。尽管在经典感觉系统中已经彻底描述了机械抑制蛋白的功能，但是内源性机械能在大脑中蜂窝功能的影响受到较少的关注，并且神经科学中的许多工作模型目前不整合细胞机制的原理。对细胞机械概念的理解对于允许将力学学集成到脑结构和功能的持续研究中必不可少。

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《Nature reviews neuroscience》 |2012年第12期|共12页
作者
William J Tyler;
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作者单位

The Virginia Tech Carilion Research Institute School of Biomedical Engineering and Sciences;

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正文语种 eng
中图分类神经生理学;
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1. The mechanobiology of brain function. [J] . William J Tyler Nature reviews neuroscience . 2012,第12期

机译：脑功能的力学生物学。
2. Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform. [J] . Ananthanarayanan B, Kim Y, Kumar S Biomaterials . 2011,第31期

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3. Daniel Amen, MD: the impact of brain imaging on psychiatry and treatment for improving brain health and function. Interview by Karen Burnett. [J] . AmenD. Alternative therapies in health and medicine . 2012,第2期

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4. Cell-matrix mechanobiology: Applications to brain tumors and design of tissue engineering scaffolds [C] . Sanjay Kumar Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2009

机译：细胞 - 矩阵力学学：应用于脑肿瘤的应用和组织工程支架的设计
5. Between the head and the heart: Cardiovascular risk factors and brain structure and cognitive function. [D] . Bancks, Michael Patrick. 2016

机译：在头部和心脏之间：心血管危险因素以及脑结构和认知功能。
6. Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform [O] . Badriprasad Ananthanarayanan, Yushan Kim, Sanjay Kumar -1

机译：使用脑基质模拟透明质酸水凝胶平台阐明恶性脑肿瘤的力学学
7. A case of arrested development of the cerebellum and its peduncles with spina bifida and other developmental peculiarities in the cord. By WB Warrington, MD MRCP, Physician to the David Lewis Northern Hospital, Liverpool, and Keith Monsarrat FRCS Edin., Surgeon to the David Lewis Northern Hospital, Liverpool. Brain 1902: 25; 444-478; with Cerebro-cerebellar agenesis in its relation to cerebellar function. By Leon Hastings Cornwall, MD, New York. Brain 1927: 50; 562-572; and Cerebellar agenesis. By Mitchell Glickstein, Department of Anatomy and Developmental Biology, University College London, UK. Brain 1994: 117; 1209-1212 [O] . A. Compston 2010

机译：一种案例，脊柱裂片和脊柱脊柱卷发和其其他发育特性的案例。由WB Warrington，MD MRCP，医生到David Lewis Northern医院，利物浦和Keith Monsarrat FRCS Edin。，外科医生到David Lewis Northern Hospital，利物浦。大脑1902：25; 444-478;脑卒中患者与小脑功能相关的刺激。由莱昂黑斯廷斯康沃尔郡，纽约MD。大脑1927：50; 562-572;和小脑刺激。由米切尔Glickstein，英国伦敦大学学院解剖和发育生物学系。大脑1994：117; 1209-1212

The mechanobiology of brain function.

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