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首页> 外文期刊>Nature reviews neuroscience >Emerging roles of astrocytes in neural circuit development.
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Emerging roles of astrocytes in neural circuit development.

机译:星形胶质细胞在神经电路开发中的新兴作用。

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摘要

Astrocytes are now emerging as key participants in many aspects of brain development, function and disease. In particular, new evidence shows that astrocytes powerfully control the formation, maturation, function and elimination of synapses through various secreted and contact-mediated signals. Astrocytes are also increasingly being implicated in the pathophysiology of many psychiatric and neurological disorders that result from synaptic defects. A better understanding of how astrocytes regulate neural circuit development and function in the healthy and diseased brain might lead to the development of therapeutic agents to treat these diseases.
机译:星形胶质细胞现在正在兴起大脑发育,功能和疾病的许多方面的关键参与者。 特别地,新的证据表明,星形胶质细胞通过各种分泌和接触介导的信号强力控制突触的形成,成熟,功能和消除。 星形胶质细胞也越来越多地涉及许多精神病和神经系统疾病的病理生理学,这是由突触缺陷引起的。 更好地了解星形胶质细胞如何调节健康和患病的脑中神经电路的发育和功能可能导致治疗剂治疗这些疾病的治疗剂。

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