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Chronic pain

机译：慢性疼痛

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Chronic pain is estimated to affect over one-quarter of the world's population, and presents a considerable therapeutic challenge. This Nature Collection brings together articles from Nature, Nature Medicine, Nature Neuroscience, Nature Reviews Neurology and Nature Reviews Neuroscience that highlight recent advances towards understanding the risk factors and mechanisms that underlie chronic pain, and developing effective, non-addictive treatments for this highly prevalent condition. Opioids are frequently prescribed to treat chronic pain, but the safety of long-term opioid therapy remains uncertain, as its use is associated with several negative outcomes, including addiction. In a News & Views article in this Collection, Filizola and Devi discuss how recently published structural data relating to the ligand-bound conformation of opioid receptors might aid the development of new drugs that retain the beneficial effects of opioids while reducing their adverse effects. Another problem is the development of opioid tolerance, which renders these compounds ineffective. This issue is addressed by Wang et al., who found that blockade of the receptor tyrosine kinase PDGFR-beta in animals could eliminate morphine tolerance without inhibiting the analgesic effects of this drug.
机译：估计慢性痛苦以影响世界上四分之一的人口，并提出了相当大的治疗挑战。本族收藏品汇集了自然，自然医学，自然神经科学，自然评论神经科和自然评论神经科学，突出最近的历史危险因素和机制，以及为这一高度普遍性地发展有效，非上瘾治疗的危险因素和机制健康）状况。阿片类药物经常被规定治疗慢性疼痛，但长期阿片类药物治疗的安全性仍然不确定，因为它的使用与包括成瘾的几种负面结果有关。在这个集合中的新闻和观点文章中，Filizola和Devi讨论了最近发表了与阿片受体的配体束缚构象有关的结构数据可能有助于开发新药，以降低其不利影响的同时保持阿片类药物的有益作用。另一个问题是开发阿片类耐受性，使这些化合物无效。该问题由Wang等人解决。王等人发现，众议院发现，动物中的受体酪氨酸激酶PDGFR-β可以消除吗啡耐受而不抑制该药物的镇痛作用。

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