Innate immune responses to trauma

Huber-Lang Markus; Lambris John D.; Ward Peter A.

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Innate immune responses to trauma

机译：天生的免疫应答对创伤

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Trauma can affect any individual at any location and at any time over a lifespan. The disruption of macrobarriers and microbarriers induces instant activation of innate immunity. The subsequent complex response, designed to limit further damage and induce healing, also represents a major driver of complications and fatal outcome after injury. This Review aims to provide basic concepts about the posttraumatic response and is focused on the interactive events of innate immunity at frequent sites of injury: the endothelium at large, and sites within the lungs, inside and outside the brain and at the gut barrier.

机译：创伤可以在任何位置和寿命的任何时间都会影响任何个体。 Macrobarriers和Microbarriers的破坏诱导了先天免疫的即时激活。随后的复杂反应，旨在限制进一步的损伤和诱导愈合，还代表了伤害后并发症和致命结果的主要驱动因素。该审查旨在为近战后反应提供基本概念，并专注于在频繁的伤害遗址：大的内皮和肺部内外的部位以及肠道屏障内的互动事件。

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《Nature immunology》 |2018年第4期|共15页
作者
Huber-Lang Markus; Lambris John D.; Ward Peter A.;
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作者单位

Univ Hosp Ulm Inst Clin &

Expt Trauma Immunol Ulm Germany;

Univ Penn Sch Med Dept Pathol &

Lab Med Philadelphia PA 19104 USA;

Univ Michigan Sch Med Dept Pathol Ann Arbor MI USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
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机译：年龄对创伤和外科重症监护单位患者严重脓毒症/脓毒症休克后天生免疫应答和结果的影响
2. Innate immune response-mediated late increase in SuPAR in multi-trauma patients [J] . K Timmermans, M Kox, M Vaneker, Critical care : . 2013,第Suppla2期

机译：先天性免疫应答介导的多发伤患者SuPAR的晚期升高
3. Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit [J] . Jon Parez-Barcena, Catalina CrespiVeronica Regueiro, Pedro MarsaJoan M Raurich, Critical care : . 2010,第6期

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4. A Temporal Analysis of the Bovine Innate Immune ResponseA Temporal Analysis of the Bovine Innate Immune Response: The Identification and Characterization of Host Defense Peptides by Mass Spectrometry [C] . Jeffrey A. DeGrasse, Jamie L. Boehmer, Kevin J. Shefcheck, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

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6. Innate immune response-mediated late increase in SuPAR in multi-trauma patients [O] . K Timmermans, M Kox, M Vaneker, 2013

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7. Effects of sequence variations in innate immune response genes on infectious outcome in trauma patients: A comprehensive review [O] . Bronkhorst M.W.G.A. (Maarten), Patka P. (Peter), Lieshout E.M.M. (Esther) van 2015

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Innate immune responses to trauma

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