Regulatory T cells in autoimmune disease

Dominguez-Villar Margarita; Hafler David A.

首页> 外文期刊>Nature immunology >Regulatory T cells in autoimmune disease

【24h】

Regulatory T cells in autoimmune disease

机译：自身免疫疾病中的调节性T细胞

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded considerably. Key observations have challenged the traditional definition of Treg cells and have provided insight into the underlying mechanisms responsible for the development of autoimmune diseases, with new therapeutic strategies that improve disease outcome. This Review summarizes the newer concepts of Treg cell instability, Treg cell plasticity and tissue-specific Treg cells, and their relationship to autoimmunity. Those three main concepts have changed the understanding of Treg cell biology: how they interact with other immune and nonimmune cells; their functions in specific tissues; and the implications of this for the pathogenesis of autoimmune diseases.

机译：近年来，对调节性T细胞（Treg Cell）生物学的理解大大扩增。关键观察挑战了Treg细胞的传统定义，并向潜在的机制介绍了负责自身免疫疾病的发展的潜在机制，具有改善疾病结果的新治疗策略。本综述总结了Treg细胞不稳定性，Treg细胞塑性和组织特异性Treg细胞的新概念及其与自身免疫的关系。这三个主要概念改变了对Treg细胞生物学的理解：它们如何与其他免疫和非免疫细胞相互作用; 它们在特定组织中的功能; 这对自身免疫疾病发病机制的影响。

著录项

来源
《Nature immunology》 |2018年第7期|共9页
作者
Dominguez-Villar Margarita; Hafler David A.;
展开▼
作者单位

Yale Sch Med Dept Neurol New Haven CT 06510 USA;

Yale Sch Med Dept Neurol New Haven CT 06510 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Ex Vivo-Expanded but Not In Vitro-Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell-Specific Demethylated Region [J] . Rossetti Maura, Spreafico Roberto, Saidin Suzan, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2015,第1期

机译：由于FOXP3调节性T细胞特异性去甲基化区域的稳定去甲基化，体外扩增但非体外诱导的人类调节性T细胞是自身免疫性疾病细胞治疗的候选者
2. B Cells with Regulatory Function in Animal Models of Autoimmune and Non-Autoimmune Diseases [J] . Mei Lin, Zuomin Wang, Xiaozhe Han Open Journal of Immunology . 2015,第1期

机译：在自身免疫性疾病和非自身免疫性疾病动物模型中具有调节功能的B细胞
3. Loss of interferon regulatory factor 8 (IRF-8) in B cells promotes the expansion of regulatory B cells (Bregs) and suppresses intraocular autoimmune disease [J] . Yu Chengrong, Lee Hyunsu, Gebreselasssie Daniel, Investigative ophthalmology & visual science . 2018,第9期

机译：B细胞中干扰素调节因子8（IRF-8）的丧失促进调节B细胞（Bregs）的扩增，并抑制眼内自身免疫疾病
4. Automatic diagnosis of autoimmune diseases by classifying HEp-2 cells [C] . Maryam A. G. Kasem, Mama M. A. Hadhoud, Mohammed A. A. ELdesoky International Computer Engineering Conference . 2017

机译：通过分类HEp-2细胞自动诊断自身免疫性疾病
5. Regulatory T cells in CD4+ T cell-mediated autoimmune diseases: Contribution to the disease development and application in the disease prevention. [D] . Zhang, Hong. 2009

机译：CD4 + T细胞介导的自身免疫性疾病中的调节性T细胞：对疾病发展的贡献以及在疾病预防中的应用。
6. B Cells with Regulatory Function in Animal Models of Autoimmune and Non-Autoimmune Diseases [O] . Mei Lin, Zuomin Wang, Xiaozhe Han -1

机译：在自身免疫性疾病和非自身免疫性疾病动物模型中具有调节功能的B细胞
7. B Cells with Regulatory Function in Animal Models of Autoimmune and Non-Autoimmune Diseases [O] . Mei Lin, Zuomin Wang, Xiaozhe Han 2015

机译：具有调节功能的B细胞在自身免疫性疾病和非自身免疫性疾病的动物模型中

Regulatory T cells in autoimmune disease

摘要

著录项

相似文献

相关主题

期刊订阅