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首页> 外文期刊>Neuron >LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells
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LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells

机译：LRRTM4：视网膜双极细胞的突触前抑制和带状突触布置的新型调节器

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摘要

LRRTM4 is a transsynaptic adhesion protein regulating glutamatergic synapse assembly on dendrites of central neurons. In the mouse retina, we find that LRRTM4 is enriched at GABAergic synapses on axon terminals of rod bipolar cells (RBCs). Knockout of LRRTM4 reduces RBC axonal GABA(A) and GABA(c) receptor clustering and disrupts presynaptic inhibition onto RBC terminals. LRRTM4 removal also perturbs the stereotyped output synapse arrangement at RBC terminals. Synaptic ribbons are normally apposed to two distinct postsynaptic "dyad" partners, but in the absence of LRRTM4, "monad" and "triad" arrangements are also formed. RBCs from retinas deficient in GABA release also demonstrate dyad mis-arrangements but maintain LRRTM4 expression, suggesting that defects in dyad organization in the LRRTM4 knockout could originate from reduced GABA receptor function. LRRTM4 is thus a key synapse organizing molecule at RBC terminals, where it regulates function of GABAergic synapses and assembly of RBC synaptic dyads.
机译：LRRTM4是一种突触型粘附蛋白调节中央神经元树突的谷氨酰胺突触突触组件。在小鼠视网膜中，我们发现LRRTM4在杆双极细胞（RBCS）的轴突终端上富集了Gabaereric突触。 LRRTM4的敲除降低了RBC轴突GABA（A）和GABA（C）受体聚类，并破坏了RBC末端的突触前抑制。 LRRTM4移除也erurbs在RBC终端的刻板输出突触布置。突触丝带通常适用于两个不同的突触后的“Dyad”合作伙伴，但在没有LRRTM4的情况下，也形成“Monad”和“三合会”布置。来自GABA释放的RETINAS的RBC也展示了Dyad MIS安排，而是维持LRRTM4表达，表明LRRTM4敲除在Dyad组织中的缺陷可以源于GABA受体功能的降低。因此，LRRTM4是RBC末端的关键Synapse组织分子，其中调节RBC突触二元的胃肠杆菌突触和组装的功能。

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  • 来源
    《Neuron》 |2020年第6期|共16页
  • 作者

    Sinha Raunak; Siddiqui Tabrez J.; Padmanabhan Nirmala; Wallin Julie; Zhang Chi; Karimi Benyamin; Rieke Fred; Craig Ann Marie; Wong Rachel O.; Hoon Mrinalini;

  • 作者单位

    Univ Wisconsin Dept Ophthalmol &

    Visual Sci Madison WI 53706 USA;

    Univ Manitoba Max Rady Coll Med Rady Fac Hlth Sci Dept Physiol &

    Pathophysiol Winnipeg MB R3E;

    Univ Manitoba Max Rady Coll Med Rady Fac Hlth Sci Dept Physiol &

    Pathophysiol Winnipeg MB R3E;

    Univ Wisconsin Dept Ophthalmol &

    Visual Sci Madison WI 53706 USA;

    Univ Washington Dept Biol Struct Seattle WA 98195 USA;

    Univ Manitoba Max Rady Coll Med Rady Fac Hlth Sci Dept Physiol &

    Pathophysiol Winnipeg MB R3E;

    Univ Washington Dept Physiol &

    Biophys Seattle WA 98195 USA;

    Univ British Columbia Djavad Mowafaghian Ctr Brain Hlth Vancouver BC V6T 2B5 Canada;

    Univ Washington Dept Biol Struct Seattle WA 98195 USA;

    Univ Wisconsin Dept Ophthalmol &

    Visual Sci Madison WI 53706 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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