Central Processing of Itch in the Midbrain Reward Center

Su Xin-Yu; Chen Ming; Yuan Yuan; Li Ying; Guo Su-Shan; Luo Huo-Qing; Huang Chen; Sun Wenzhi; Li Yong; Zhu Michael X.; Liu Ming-Gang; Hu Ji; Xu Tian-Le

首页> 外文期刊>Neuron >Central Processing of Itch in the Midbrain Reward Center

【24h】

Central Processing of Itch in the Midbrain Reward Center

机译：中脑奖励中心瘙痒的中央加工

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Itch is an aversive sensation that evokes a desire to scratch. Paradoxically, scratching the itch also produces a hedonic experience. The specific brain circuits processing these different aspects of itch, however, remain elusive. Here, we report that GABAergic (GABA) and dopaminergic (DA) neurons in the ventral tegmental area (VTA) are activated with different temporal patterns during acute and chronic itch. DA neuron activation lags behind GABA neurons and is dependent on scratching of the itchy site. Optogenetic manipulations of VTA GABA neurons rapidly modulated scratching behaviors through encoding itch-associated aversion. In contrast, optogenetic manipulations of VTA DA neurons revealed their roles in sustaining recurrent scratching episodes through signaling scratching-induced reward. A similar dichotomy exists for the role of VTA in chronic itch. These findings advance understanding of circuit mechanisms of the unstoppable itch-scratch cycles and shed important insights into chronic itch therapy.

机译：痒是一种厌恶的感觉，唤起了对划伤的愿望。矛盾的是，抓痒的痒也会产生蜂窝体验。然而，处理这些不同方面的特定脑电路仍然难以捉摸。在此，我们报告说，在急性和慢性瘙痒期间用不同的时间模式激活腹侧传神面积（VTA）中的胃肠杆菌（GABA）和多巴胺能（DA）神经元。 Da Neuron活化滞后于GABA神经元，依赖于瘙痒部位。 VTA GABA神经元的致敏操纵通过编码瘙痒相关的厌恶来快速调制刮擦行为。相比之下，VTA Da神经元的致敏操纵揭示了通过信号划伤引起的奖励来维持复发性刮擦发作的作用。存在类似的二分法，用于VTA在慢性瘙痒中的作用。这些发现提前了解不可阻挡的痒 - 划痕循环的电路机制，并将重要见解进入慢性瘙痒疗法。

著录项

来源
《Neuron》 |2019年第4期|共20页
作者
Su Xin-Yu; Chen Ming; Yuan Yuan; Li Ying; Guo Su-Shan; Luo Huo-Qing; Huang Chen; Sun Wenzhi; Li Yong; Zhu Michael X.; Liu Ming-Gang; Hu Ji; Xu Tian-Le;
展开▼
作者单位

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat &

Physiol Shanghai;

ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China;

ShanghaiTech Univ Sch Life Sci &

Technol Shanghai 201210 Peoples R China;

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat &

Physiol Shanghai;

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat &

Physiol Shanghai;

ShanghaiTech Univ Sch Life Sci &

Technol Shanghai 201210 Peoples R China;

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat &

Physiol Shanghai;

ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China;

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Biochem &

Mol Cell Biol;

Univ Texas Hlth Sci Ctr Houston McGovern Med Sch Dept Integrat Biol &

Pharmacol Houston TX;

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat &

Physiol Shanghai;

ShanghaiTech Univ Sch Life Sci &

Technol Shanghai 201210 Peoples R China;

Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat &

Physiol Shanghai;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经病学;
关键词

相似文献

外文文献
中文文献
专利

1. Central processing of itch in the midbrain reward center [J] . Xin-Yu Su, Ming Chen, Tian-Le Xu IBRO Reports . 2019,第4期

机译：中脑奖励中心的瘙痒集中处理
2. Cortical visual processing evokes short-latency reward-predicting cue responses in primate midbrain dopamine neurons [J] . Norihiro Takakuwa, Peter Redgrave, Tadashi Isa Scientific reports. . 2018,第1期

机译：皮质视觉处理在灵长类中脑多巴胺神经元中引起短时奖励预测的提示反应。
3. Midbrain-Driven Emotion and Reward Processing in Alcoholism [J] . E M Müller-Oehring, Y-C Jung, E V Sullivan, Neuropsychopharmacology . 2013,第10期

机译：酗酒中脑驱动的情绪和奖励处理
4. SpanEdge: Towards Unifying Stream Processing over Central and Near-the-Edge Data Centers [C] . Hooman Peiro Sajjad, Ken Danniswara, Ahmad Al-Shishtawy, The First IEEE/ACM Symposium on Edge Computing . 2016

机译：SpanEdge：致力于统一中央和近端数据中心上的流处理
5. Petrology of Quaternary volcanics of the Broken Top and Diamond Peak areas, central and south-central Oregon High Cascades: Evidence for varied magmatic processes from two contrasting volcanic centers. [D] . Webster, John Robert. 1992

机译：俄勒冈中部和中南部高断层破碎山顶和钻石峰地区的第四纪火山岩岩石学：来自两个相反的火山中心的岩浆作用变化的证据。
6. Midbrain-Driven Emotion and Reward Processing in Alcoholism [O] . E M Müller-Oehring, Y-C Jung, E V Sullivan, 2013

机译：酗酒中脑驱动的情绪和奖励处理
7. Acute opioid withdrawal is associated with increased neural activity in reward-processing centers in healthy men: A functional magnetic resonance imaging study [O] . Chu Larry F., Lin Joanne C., Clemenson Anna, 2015

机译：功能性磁共振成像研究表明，在健康男性中，急性阿片类药物戒断与奖励处理中心神经活动增强有关

Central Processing of Itch in the Midbrain Reward Center

摘要

著录项

相似文献

相关主题

期刊订阅