Breaching the Blood-Brain Barrier for Drug Delivery

BellR.; EhlersM.

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Breaching the Blood-Brain Barrier for Drug Delivery

机译：违反血脑屏障进行药物递送

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Molecular "hitchhiking" through receptor-mediated transcytosis at the blood-brain barrier is a CNS drug delivery strategy. In this issue of Neuron, Niewoehner etal. (2014) describe a modular anti-transferrin receptor Fab approach for shuttling therapeutic antibodies into the brain.

机译：通过受体介导的血脑屏障的受体介导的转胞增分的分子“搭便车”是CNS药物递送策略。在这个神经元的问题中，Niewoehner etal。（2014）描述一种用于将治疗性抗体穿梭到大脑中的模块化抗转铁蛋白受体Fab方法。

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《Neuron》 |2014年第1期|共3页
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BellR.; EhlersM.;
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Neuroscience Research Unit Pfizer Worldwide Research and Development 610 Main Street Cambridge;

Neuroscience Research Unit Pfizer Worldwide Research and Development 610 Main Street Cambridge;

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正文语种 eng
中图分类神经病学;
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专利

1. Breaching the Blood-Brain Barrier for Drug Delivery [J] . BellR., EhlersM. Neuron . 2014,第1期

机译：突破药物输送的血脑屏障
2. Commentary on "Alzheimer's disease drug development and the problem of the blood-brain barrier." Alzheimer's disease drugs: more than one barrier to breach. [J] . Roher AE, Kokjohn TA Alzheimer’s & dementia: the journal of the Alzheimer’s Association . 2009,第5期

机译：关于“阿尔茨海默氏病药物开发和血脑屏障问题的评论”。阿尔茨海默氏病药物：突破壁垒不止一种。
3. From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery [J] . Banks William A. Nature reviews Drug discovery . 2016,第4期

机译：从血脑屏障到血脑界面：中枢神经系统药物输送的新机遇
4. The Laser Technologies of Targeted Opening of Blood-Brain Barrier for Drug Brain Delivery [C] . O.V. Semyachkina-Glushkovskaya, E.U. Rafailov, S.G. Sokolovsky, 2018 International Conference Laser Optics . 2018

机译：靶向开放血脑屏障药物脑传递的激光技术
5. Targeting Organic Anion Transporting Polypeptide 1a4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier [D] . Abdullahi, Wazir. 2019

机译：靶向有机阴离子转运多肽1a4（Oatp1a4）以有效地在血脑屏障处进行药物输送
6. Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study [O] . Wenbo Zhan 2020

机译：聚焦超声和微泡诱导的血脑屏障破坏对脂质在脂质体介导的脑肿瘤中转运的影响：数值模拟研究。
7. Breaching the Blood-Brain Barrier for Drug Delivery [O] . Bell Robert D., Ehlers Michael D. 2014

机译：突破药物输送的血脑屏障

Breaching the Blood-Brain Barrier for Drug Delivery

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