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首页> 外文期刊>Neuron >Neuronal Ig/Caspr Recognition Promotes the Formation of Axoaxonic Synapses in Mouse Spinal Cord
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Neuronal Ig/Caspr Recognition Promotes the Formation of Axoaxonic Synapses in Mouse Spinal Cord

机译：神经元Ig / Caspr识别促进小鼠脊髓中腋x突触的形成

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摘要

Inhibitory microcircuits are wired with a precision that underlies their complex regulatory roles in neural information processing. In the spinal cord, one specialized class of GABAergic interneurons (GABApre) mediates presynaptic inhibitory control of sensory-motor synapses. The synaptic targeting of these GABAergic neurons exhibits an absolute dependence on proprioceptive sensory terminals, yet the molecular underpinnings of this specialized axoaxonic organization remain unclear. Here, we show that sensory expression of an NB2 (Contactin5)/Caspr4 coreceptor complex, together with spinal interneuron expression of NrCAM/CHL1, directs the high-density accumulation of GABAergic boutons on sensory terminals. Moreover, genetic elimination of NB2 results in a disproportionate stripping of inhibitory boutons from high-density GABApre-sensory synapses, suggesting that the preterminal axons of GABApre neurons compete for access to individual sensory terminals. Our findings define a recognition complex that contributes to the assembly and organization of a specialized GABAergic microcircuit.
机译：抑制微电路的连接是一种精确度，使其在神经信息处理中进行复杂的调节作用。在脊髓中，一类专门的加布曲线（Gabapre）介导感觉电动机突触的突触前抑制控制。这些加布性神经元的突触靶向表现出对血管活性感官终端的绝对依赖性，但这种专门的腋x型组织的分子下限仍然不清楚。这里，我们表明NB2（POLEDIN5）/ CACPR4团体复合物的感官表达与NRCAM / CHL1的脊髓性局部表达一起引导了在感觉终端上的GABAergic Buton的高密度积累。此外，Nb2的遗传消除导致来自高密度加布曲面突触的抑制抑制抑制抑制件的剥离，这表明加布普雷神经元的预态轴突竞争获得各个感官终端。我们的调查结果定义了一种识别复杂，有助于组装和组织专用的加布性微电路。

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  • 来源
    《Neuron》 |2014年第1期|共10页
  • 作者

    AshrafiS.; BetleyJ.; ComerJ.; Brenner-MortonS.; BarV.; ShimodaY.; WatanabeK.; PelesE.; JessellT.; KaltschmidtJ.;

  • 作者单位

    Weill Cornell Graduate School of Medical Sciences New York NY 10065 United States Sloan;

    Howard Hughes Medical Institute Kavli Institute of Brain Science Departments of Neuroscience;

    Weill Cornell Graduate School of Medical Sciences New York NY 10065 United States Sloan;

    Howard Hughes Medical Institute Kavli Institute of Brain Science Departments of Neuroscience;

    Department of Molecular Cell Biology The Weizmann Institute of Science Rehovot 76100 Israel;

    Department of Bioengineering Nagaoka University of Technology 1603-1 Kamitomiokamachi Nagaoka;

    Department of Bioengineering Nagaoka University of Technology 1603-1 Kamitomiokamachi Nagaoka;

    Department of Molecular Cell Biology The Weizmann Institute of Science Rehovot 76100 Israel;

    Howard Hughes Medical Institute Kavli Institute of Brain Science Departments of Neuroscience;

    Weill Cornell Graduate School of Medical Sciences New York NY 10065 United States Sloan;

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  • 正文语种 eng
  • 中图分类 神经病学;
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