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Olfactory receptor and neural pathway responsible for highly selective sensing of musk odors

机译：嗅觉受体和神经途径，负责高度选择性的麝香味道

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摘要

Musk odorants are used widely in cosmetic industries because of their fascinating animalic scent. However, how this aroma is perceived in the mammalian olfactory system remains a great mystery. Here, we show that muscone, one musk odor secreted by various animals from stink glands, activates a few glomeruli clustered in a neuroanatomically unique anteromedial olfactory bulb. The muscone-responsive glomeruli are highly specific to macrocyclic ketones; interestingly, other syntheticmusk odorants with nitro or polycyclic moieties or ester bonds activate distinct but nearby glomeruli. Anterodorsal bulbar lesions cause muscone anosmia, suggesting that this region is involved in muscone perception. Finally, we identified the mouse olfactory receptor, MOR215-1, that was a specific muscone receptor expressed by neurons innervating the muscone-responsive anteromedial glomeruli and also the human muscone receptor, OR5AN1. The current study documents the olfactory neural pathway in mice that senses and transmits musk signals from receptor to brain.
机译：由于他们迷人的动物气味，麝香味道在化妆品行业中广泛使用。然而，这种香气在哺乳动物嗅觉系统中是如何感知的仍然是一个伟大的谜。在这里，我们表明，由来自臭腺体分泌的各种动物分泌的麝香酮，在神经杀菌独特的前嗅液体中激活几种细胞聚集在一起。麝香酮响应性肾小球对大环酮具有高度特异性;有趣的是，其他合成的含有硝基或多环部分或酯键的异味剂激活，但附近的肾小球附近。亚脉冲泡片病变导致麝香酮Anosmia，表明该地区涉及肌肉肌肉感知。最后，我们鉴定了小鼠嗅觉受体，Mor215-1，其是由神经元表示的特异性麝香酮受体，所述神经元称测肌肉响应的前毛细管和人麝香酮受体，OR5An1。目前的研究记录了小鼠中的嗅觉神经途径，从受体到脑中感测和透射麝香信号。

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  • 来源
    《Neuron》 |2014年第1期|共14页
  • 作者

    ShirasuM.; YoshikawaK.; TakaiY.; NakashimaA.; TakeuchiH.; SakanoH.; TouharaK.;

  • 作者单位

    Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The;

    Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The;

    Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The;

    Department of Brain Function School of Medical Science University of Fukui Fukui 910-1193 Japan;

    Department of Brain Function School of Medical Science University of Fukui Fukui 910-1193 Japan;

    Department of Brain Function School of Medical Science University of Fukui Fukui 910-1193 Japan;

    Department of Applied Biological Chemistry Graduate School of Agricultural and Life Sciences The;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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